留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

中药治疗幽门螺杆菌相关性胃炎的研究进展

奚肇宏 夏军权 滑永志

奚肇宏, 夏军权, 滑永志. 中药治疗幽门螺杆菌相关性胃炎的研究进展[J]. 南京中医药大学学报, 2018, 34(4): 429-432.
引用本文: 奚肇宏, 夏军权, 滑永志. 中药治疗幽门螺杆菌相关性胃炎的研究进展[J]. 南京中医药大学学报, 2018, 34(4): 429-432.
XI Zhao-hong, XIA Jun-quan, HUA Yong-zhi. Research Progress of Chinese Medicine in the Treatment of Helicobacter Pylori-Associated Gastritis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2018, 34(4): 429-432.
Citation: XI Zhao-hong, XIA Jun-quan, HUA Yong-zhi. Research Progress of Chinese Medicine in the Treatment of Helicobacter Pylori-Associated Gastritis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2018, 34(4): 429-432.

中药治疗幽门螺杆菌相关性胃炎的研究进展

Research Progress of Chinese Medicine in the Treatment of Helicobacter Pylori-Associated Gastritis

  • 摘要: 幽门螺杆菌是慢性胃炎的主要致病因子,近年来其感染率逐渐增高。中医药在治疗幽门螺杆菌相关性胃炎方面优势显著,副作用小,耐药率低。基于目前中医药治疗幽门螺杆菌相关性胃炎的研究进展,从证候特点、常用中药及其活性成分、作用机制和相关研究方法的角度进行综述,以期为相关中药复方中活性成分的辨识研究提供参考。<

     

  • [1] SIEGEL R,MA J,ZOU Z,et al. Cancer statistics[J]. CA Cancer J Clin,2014,64:929.〖ZK)〗
    [2] FARRELL P. Pathogenesis:Infections causing gastric cancer[J]. Nat Microbiol, 2016,1:16038.〖ZK)〗
    [3] VALLVE M,VERGARA M,GISBERT JP,et al. Single vs. double dose of a proton pump inhibitor in triple therapy for Helicobacter pylori eradication: ametaanalysis[J]. Aliment Pharmacol Ther,2002,16(6):11491156.〖ZK)〗
    [4] 张万岱,胡伏莲,萧树东,等.中国自然人群幽门螺杆菌感染的流行病学调查[J].现代消化及介入诊疗,2010,15(5):265270.〖ZK)〗
    [5] KIM SS,RUIZ VE,CARROLL JD,et al. Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma[J]. Cancer Lett,2011,305(2):228238.〖ZK)〗
    [6] 俞芹,沈宇清,钱建业,等. 从浊毒论治幽门螺杆菌相关性胃炎体会[J].中医药学报,2014,42(1):3738.〖ZK)〗
    [7] 中华中医药学会. 中医体质分类与判定(ZYYXH/T157-2009)[J]. 世界中西医结合杂志,2009,4(4):303304.〖ZK)〗
    [8] 谢峰. 幽门螺杆菌相关性胃炎患者中医体质类型与中医证型关系的初步研究[D].南京:南京中医药大学,2010.〖ZK)〗
    [9] 张显涛,沈洪,刘亚军,等.中医药治疗幽门螺杆菌相关性胃炎研究进展[J].辽宁中医药大学学报,2013,15(5):8587.〖ZK)〗
    [10] 杨雯,杨卫京,王素青.金铃调胃汤治疗肝胃不和型慢性浅表性胃炎30例临床疗效观察[J].河北中医,2012,34(3):334336.〖ZK)〗
    [11] 张晓殷,李克强. 清幽汤辨证治疗幽门螺杆菌感染相关性胃病168例[J]. 中国社区医师,2011,13(5):113.〖ZK)〗
    [12] 谢静芳,金小晶. 中药复方治疗幽门螺杆菌相关性胃病[J].河南中医,2013,33(4):543545.〖ZK)〗
    [13] 沈正泽,古锐,曾宪泉,等. 基于数据挖掘的中药专利复方治疗幽门螺杆菌相关性胃病的用药规律分析[J].中国中西医结合消化杂志,2016,24(8):608611.〖ZK)〗
    [14] 王建平,彭孝纬. 单味中药治疗幽门螺杆菌的动物研究[J].胃肠病学和肝病学杂志,2010,19(4):345347.〖ZK)〗
    [15] SWAMY M,SINNIAH U. A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth: an aromatic medicinal plant of industrial importance[J]. Molecules,2015,20:85218547.〖ZK)〗
    [16] ZHENG Y,XIE J,XU Y,et al. Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stressinduced ulcer in rats[J]. Chem Biol Interact,2014,222:2736.〖ZK)〗
    [17] YU X,XIE J,WANG Y,et al. Selective antibacterial activity of patchouli alcohol against Helicobacter pylori based on inhibition of urease[J]. Phytother Res,2015,29:6772.〖ZK)〗
    [18] XIE J,LIN Z,XIAN Y,et al. (-)Patchouli alcohol protects against Helicobacter pylori ureaseinduced apoptosis, oxidative stress and inflammatory response in human gastric epithelial cells[J]. Int Immunopharmacol,2016,35:4352.〖ZK)〗
    [19] XU YF,LIAN DW,CHEN YQ,et al. In Vitro and In Vivo Antibacterial Activities of Patchouli Alcohol, a Naturally Occurring Tricyclic Sesquiterpene, against Helicobacter pylori Infection[J]. Antimicrob Agents Chemother,2017,24:61(6). pii:e0012217.〖ZK)〗
    [20] 董凤.中药成分对多重耐药性幽门螺杆菌的体外抑菌作用[J].中西医结合心血管病电子杂志,2017,5(15):78.〖ZK)〗
    [21] 陈宁南,万强. 小檗碱减轻幽门螺杆菌诱导的人胃黏膜上皮细胞损伤[J].中国病理生理杂志,2017,33(12):22832286,2292.〖ZK)〗
    [22] CHANG CH,WU JB,YANG JS,et al. The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections in vitro and in vivo[J]. J Food Sci,2017 ,82(12):30213028.〖ZK)〗
    [23] ISLAM MM,KUMAR GS. RNA targeting by small molecule alkaloids:Studies on the binding of berberine and palmatine to polyribonucleotides and comparison to ethidium[J]. Journal of Molecular Structure,2008,875(1/2/3):382391.〖ZK)〗
    [24] JUNG J,CHOI JS,JEONG CS. Inhibitory Activities of Palmatine from Coptis chinensis Against Helicobactor pylori and Gastric Damage[J]. Toxicol Res,2014,30(1):4548.〖ZK)〗
    [25] ZHOU JT,LI CL,TAN LH,et al. Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism[J]. PLoS One,2017,12(1):e0168944.〖ZK)〗
    [26] LEE JW, MASE N, YONEZAWA T,et al. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factorκb ligand expression in osteoblast cells[J]. Biol Pharm Bull,2010,33(10):17331739.〖ZK)〗
    [27] 吴明慧,黄衍强,黄赞松,等.黄连素、大黄素、五味子及黄芩苷对幽门螺杆菌多重耐药株的体外抑菌作用[J]. 世界华人消化杂志,2013,21(30):32473251.〖ZK)〗
    [28] 彭如洁,彭孝纬. 维生素 C、白藜芦醇和大黄素对幽门螺杆菌体外抗菌作用的研究[J]. 中国中医药咨讯,2012,3(23):5152.〖ZK)〗
    [29] 吴静,胡东,王克霞. 黄芩和黄芩苷对幽门螺杆菌的体外抗菌活性研究[J]. 中药材,2008,31(5): 707710.〖ZK)〗
    [30] FOLLMER C. Ureases as a target for the treatment of gastric and urinary infections[J]. J Clin Pathol,2010,63(5):424430.〖ZK)〗
    [31] MENARD R,SCHOENHOFEN I,TAO L,et al. Smallmolecule inhibitors of the pseudaminic acid biosynthetic pathway: targeting motility as a key bacterial virulence factor[J]. Antimicrob Agents Chemother,2014,58:74307440.〖ZK)〗
    [32] ODENBREIT S. Adherence properties of Helicobacter pylori: impact on pathogenesis and adaptation to the host[J]. Int J Med Microbiol,2005,295:317324.〖ZK)〗
    [33] YOSHIYAMA H,NAKAZAWA T. Unique mechanism of Helicobacter pylori for colonizing the gastric mucus[J]. Microbes Infect,2000,2:5560.〖ZK)〗
    [34] KI MR,HWANG M,KIM AY,et al. Role of vacuolating cytotoxin VacA and cytotoxinassociated antigen CagA of Helicobacter pylori in the progression of gastric cancer[J]. Mol Cell Biochem,2014,396(1/2):2332.〖ZK)〗
    [35] HUANG F,CHAN A,LO R,et al. Characterization of interleukin1β in Helicobacter pyloriinduced gastric inflammation and DNA methylation in interleukin1 receptor type 1 knockout (IL1R1/) mice[J]. Eur J Cancer,2013,49:27602770.〖ZK)〗
    [36] DUNNE C,DOLAN B,CLYNE M. Factors that mediate colonization of the human stomach by Helicobacter pylori[J]. World J Gastroenterol,2014,20:56105624.〖ZK)〗
    [37] KIM I,BLANKE S. Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA)[J]. Front Cell Infect Microbiol,2014,2:37.〖ZK)〗
    [38] JONES KR,WHITMIRE JM,MERREKK DS. A tale of 2 toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease[J]. Front Microbiol,2010,1:115.〖ZK)〗
    [39] FIGUEIREDO CA,MARQUES CR,COSTA RS,et al. Cytokines,cytokine gene polymorphisms, and Helicobacter pylori infection: friend or foe[J]. World J Gastroenterol,2014,20(18):52355243.〖ZK)〗
    [40] YEO M,PARK H,KIM D,et al. Restoration of heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase expression induced by Helicobacter pylori[J]. Proteomics,2004,4:33353342.〖ZK)〗
    [41] WANG H,SUN Y,LIU S,et al. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway:Role in epithelial cell proliferation and migration[J]. FEMS Immunol,2011,63:8292.〖ZK)〗
    [42] RYSZCZUK E,ROSZKOKIRPSZA I,GUZINSKAUSTYMOWICZ K,et al. EGFR and Bcl2 in gastric mucosa of children infected with Helicobacter pylori[J]. Postepy Hig,2016,70:258264.〖ZK)〗
    [43] ZHANG S,HUANG J,XIE XQ,et al. Quercetin from polygonum capitatum protects against gastric inflammation and apoptosis associated with helicobacter pylori infection by affecting the levels of p38MAPK, Bcl2 and BAX[J]. Molecules,2017,22(5): pii: E744.〖ZK)〗
    [44] LOH J,GADDY J,ALGOOD H,et al. Helicobacter pylori adaptation in vivo in response to a highsalt diet[J]. Infect Immun,2015,83:48714883.〖ZK)〗
    [45] SI L,LI P,LIU X,et al. Chinese herb medicine against Sortase A catalyzed transformations, a key role in grampositive bacterial infection progress[J]. J Enzym Inhib Med Chem,2016,31:184196.〖ZK)〗
    [46] 王灯节,刘廷,狄留庆,等. 中药制剂指标性成分群辨识思路与方法解析[J].中草药,2015,46(23):34473454.〖ZK)〗
  • 加载中
计量
  • 文章访问数:  1446
  • HTML全文浏览量:  17
  • PDF下载量:  1198
  • 被引次数: 0
出版历程
  • 刊出日期:  2018-07-10

目录

    /

    返回文章
    返回