Abstract: This paper introduces the philosophy and method of regulating and treating polycystic ovary syndrome (PCOS) by TCM master Xia Guicheng. Circular motion biological clock rhythm of female reproductive axis was analyzed with the concept of waxing and waning， conversion of yin and yang in Tai Chi of Yi-ology. He proposes heart-kidney interaction， priority of balancing yin and yang， coordination of liver and spleen， qi and blood， and regulating the changes of menstruation cycle to treat menstrual disorder. It is believed that the disorder of the circular motion biological clock rhythm of reproductive axis is the source of PCOS. Dysfunction of main zang-fu organs is the key of PCOS， including lack of essence-generation source due to the insufficiency of reproduction-stimulating essence， rhythm disorder due to non-interaction between the heart and the kidney， yin deficiency with yang hyperactivity due to insufficiency of liver-yin， phlegm and fat causing disease due to spleen and stomach. The dysfunction of storing and discharging of extraordinary fu organs is the apparent factor of menstruation disorder in PCOS.