金线莲液治疗儿童白血病化疗后口腔溃疡的临床研究

李芹; 黄伟; 周文; 李健; 陈再生

金线莲液治疗儿童白血病化疗后口腔溃疡的临床研究

李芹^1,,
黄伟¹,
周文¹,
李健²,
陈再生²

1.
福州市传染病医院中西医结合科，福建福州 350001
2.
福建医科大学附属协和医院，福建福州 350001

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出版历程
- 收稿日期: 2016-04-16
- 修回日期: 2016-07-01
- 刊出日期: 2016-09-10

Clinical Study of Anoectochilus Roxburghii Liquid in Treating Oral Ulcer Due to Chemotherapy for Childhood Leukemia

1.
Integrated TCM and Western Medicine Department, Fuzhou Infectious Hospital, Fuzhou, 350001, China
2.
Union Hospital Affiliated to Fujian Medical University, Fuzhou, 350001, China

摘要

摘要: 目的观察金线莲液对儿童白血病化疗后出现口腔溃疡的临床疗效。方法将符合标准的儿童白血病化疗后出现口腔溃疡76例患儿随机分为开喉剑组40例（对照组）和金线莲液组36例（试验组），比较2组患者经过不同方案治疗前后口腔黏膜破溃分度情况、口腔溃疡疼痛评分以及总体临床疗效。结果试验组在缩小口腔溃疡面积、缓解疼痛方面较对照组效果明显（P<0.05），口腔溃疡分级情况比对照组口腔溃疡分级愈合情况更好（P<0.01），临床疗效优于对照组（P<0.05）。2组患者在治疗过程中均无明显不良反应。结论金线莲液治疗儿童白血病化疗后出现的口腔溃疡临床效果明显优于开喉剑喷雾剂。
- 金线莲液 /
- 儿童白血病 /
- 口腔溃疡
Abstract: OBJECTIVE To observe the clinical effects of Anoectochilus Roxburghii liquid in treating oral ulcer due to chemotherapy for childhood leukemia. METHODS 76 children with oral ulcer due to chemotherapy for childhood leukemia were randomly divided into control group(40 cases) treated with Kaijiankou Sprayer and treatment group(36 cases) treated with Anoectochilus Roxburghii liquid. Mouth ulceration and its pain degree of both groups were compared before and after treatment together with the total clinical effects. RESULTS The treatment group possessed evident advantages over the control group in improving oral ulcerative areas(P<0.05). The treatment group was superior in relieving the pain to the control group(P<0.05). And the ulcer classification of the treatment group was better than that of the control group(P<0.05). No evident side effects were detected in the two groups. CONCULSION Anoectochilus Roxburghii liquid has better clinical effects than Kaijiankou sprayer in treating oral ulcer due to chemotherapy for childhood leukemia， which deserves wide clinical application and promotion.
- Anoectochilus Roxburghii liquid /
- childhood leukemia /
- oral ulcer

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参考文献(11)

[1]	黄伟，李芹，周文，等.中西医治疗白血病化疗后口腔溃疡临床研究进展[J].中国中医急症，2016，25，(4):672-674.
[2]	HUANG W， LI Q， ZHOU W， et al. Clinical research progress of integrated traditional Chinese and western medicine in treating oral ulcer due to leukemia after chemotherapy[J]. J Emerg Tradit Chin Med， 2016， 25， (4): 672-674.
[3]	张友明，徐建峰，江东俊.益气养营方配合康复新液治疗复发性口腔溃疡的临床疗效[J]. 中国现代药物应用，2011，5(6):100-101.
[4]	ZHANG YJ， XU JF， JIANG DJ. Clinical curative effect of Yiqi Yingyang Formula combined with Kangfuxin Formula in treating recurrent oral ulceration[J]. Chin J Mod Drug Appl， 2011， 5(6): 100-101.
[5]	韩少良，邵永孚.癌症化学治疗的毒副反应及其处理[M].上海:复旦大学出版社，2001:123．
[6]	HAN SL， SHAO YF. Toxic and Side Effects of Cancer Chemotherapy and Its Treatment[M]. Shanghai: Fudan university press， 2001: 123.
[7]	中华口腔医学会口腔黏膜病专业委员会.复发性阿弗它溃疡疗效评价试行标准[J].实用口腔医学杂志，2001，17(4):277.
[8]	Chinese Stomatological Association Professional Committee of Oral Mucosal Disease. Curative effect evaluation criteria for recurrent aphthous ulcer[J]. J Pract Stomatol， 2001， 17(4): 277.
[9]	SIVINA M， HARTMANN E，VASYUTINA E，et al. Stromal cells modulate TCL1 expression，interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocyticleukemia[J]. Leukemia，2012，26(8):1812-1820.
[10]	李芹，周文，刘路，等.金线莲喷雾剂治疗手足口病口腔疱疹临床观察[J].福建中医药，2012，43(3):9-10.
[11]	LI Q， ZHOU W， LIU L， et al. Clinical observation of Kaijiankou Sprayer in treating oral herpes caused by hand-foot-and-mouth disease[J]. Fujian J Tradit Chin Med， 2012， 43(3): 9-10.