高血压病阴虚阳亢证的基因网络研究
The Study of Gene Network of Yin Deficiency and Yang Excess Syndrome of Essential Hypertension
-
摘要: 目的 探讨高血压病阴虚阳亢证的相关基因网络关系,为该病辨治机理提供支持。方法 搜索文献中高血压病阴虚阳亢证的相关基因,运用CYTOSCAPE进行网络构建,MCODE进行模块划分,对重要模块进行功能与通路分析。结果 高血压病阴虚阳亢证基因网络含基因最多的模块中,共有17个基因涉及血管重构、调节血管平滑肌细胞增殖和调控凋亡生物学过程,与MAPK信号通路、Toll样受体信号通路和NOD样受体信号通路相关;基因联系频数最高的是VEGFA、ACE、MAPK9。结论 VEGFA、ACE、MAPK9基因是网络中联系最为密切的基因,血管重构、MAPK信号通路分别是联系最为密切的生物功能与通路。Abstract: OBJECTIVE To study the gene network of yin deficiency and yang excess syndrome of essential hypertension to support the syndrome differentiation. METHODS Genes related to yin deficiency and yang excess syndrome of essential hypertension were collected from the literatures and CYTOSCAPE was used for the network construction and MCODE for modularized analysis. After that, a functional enrichment analysis was performed to find the biological processes and pathways of the most important modules. RESULTS The modules containing most genes had 17 genes which were related to vascular remodeling, vascular smooth muscle cell proliferation regulating, apoptosis regulating, MAPK signal pathway, Toll-like receptors signal pathway and NOD-like receptors signal pathway. VEGFA, ACE and MAPK9 had the highest genetic link frequency. CONCLUSION VEGFA, ACE and MAPK9 have the strongest connection in the network. Vascular remodeling has the strongest connection with MAPK signal pathway.
-
[1] 唐靖一,王佑华,汤诺高,等.高血压病中医证型与COX-2基因多态性的相关性研究[J].上海中医药大学学报,2012,26(3) :32-36. [2] Tang JY, Wang YH, Tang N, et al. Correlativity between patterns of hypertension in TCM and polymorphism of COX-2[J]. J Shanghai Univ Chin Med, 2012, 26(3):32-36. [3] Nair J,Ghatge M,Kakkar VV,et al.Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease[J]. PloS One,2014,9(4):e94328. [4] Bader GD,Hogue WV.An automated method for finding molecular complexes in large protein interaction networks[J].BMC Bioinform,2003,4(1):4-6. [5] 王博,张继东,冯进波,等.芩丹胶囊对自发性高血压大鼠血管重构以及骨桥蛋白基因表达的影响[J].南京中医药大学学报,2007,23(3):157-160. [6] Wang B, Zhang JD, Feng JB, et al. The influence of QinDan capsule to the vascular remolding and Osteopontin gene expression of essential hypertension rats[J]. J Nanjing Univ Chin Med, 2007, 23(3):157-160. [7] 董昌武,董梅,邢齐树,等.原发性高血压患者中医辨证分型与ACE 基因I/D多态性的相关性研究[J].中医病理生理杂志,2010,26(8):1545-1548. [8] Dong CW, Dong M, Xin QS. Primary study on correlation of hypertension syndrome patient and ACE syndrome gene polymorphism distribution[J].Chin J Pathophysi,2010,26(8):1545-1548. [9] 蔡三郎.中药复方对SHR血管重构及肾素-血管紧张素系统的治未病效应[D].广州:广州中医药大学,2007. [10] Cai SL.Study on the ear1y treatment of reversing vascular remodeling and renin-angiotensin system[D]. Guangzhou: Guangzhou University of Chinese Medicine, 2007. [11] Timasheva YR, Nasibullin TR, Imaeva EB, et al. Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia[J].Clin Exp Hypertens,2015,37(5):398-403. [12] 钟广伟,李炜,陈民敬,等.天麻、钩藤、石决明、牡蛎、牛膝混合剂对高血压大鼠血管重构的影响[J].中华高血压杂志,2008,16(9):812-816. [13] Zhong GW, Li W, Chen MJ, et al. Effects on the vascular remolding and adipnectin expression in aorta in the spontaneously hypertensive by Chinese herb mixture method[J].Chin J Hypert, 2008, 16(9):812-816.
点击查看大图
计量
- 文章访问数: 738
- HTML全文浏览量: 5
- PDF下载量: 642
- 被引次数: 0