心衰Ⅰ号对慢性收缩性心力衰竭的临床研究

赵惠; 李七一; 张琪; 赵坤元

心衰Ⅰ号对慢性收缩性心力衰竭的临床研究

1.
南京中医药大学附属医院，江苏南京 210029
2.
常州市中医医院心血管内科，江苏常州 213003
3.
昆山市中医院心血管内科，江苏昆山 215300

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出版历程
- 收稿日期: 2012-10-15
- 修回日期: 2013-01-13
- 刊出日期: 2013-03-10

Clinical Research on XinshuaiⅠfor Chronic Systolic Heart Failure

1.
The Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, 210029, China
2.
Cardiovascular Department of Changzhou TCM Hospital, Changzhou, 213003, China
3.
Cardiovascular Department of Kunshan TCM Hospital, Kunshan, 215300, China

摘要

摘要: 目的评价具有益气养阴、活血化痰作用的心衰Ⅰ号配方颗粒（心衰Ⅰ号）对慢性收缩性心力衰竭（CHF）的治疗效果。方法将120例CHF患者随机分为治疗组与对照组，每组60例，2组在西医治疗的基础上治疗组口服心衰Ⅰ号，每日1袋，分2次服，对照组口服心衰Ⅰ号安慰剂，每日1袋，分2次服。4周为1个疗程，观察时间为6个疗程。比较2组治疗后症状、体征、生活质量评分、脑钠肽（BNP）、左室射血分数（LVEF）、6 min步行试验（6MWT）的变化和综合疗效。结果 2组治疗前后对比在症状、体征、综合疗效、BNP、LVEF、6MWT等方面有显著性差异(P<0.05)；治疗组总有效率为67.24%，对照组总有效率为45.61%，组间对比治疗组优于对照组(P<0.05)；治疗期间2组均无不良反应发生。结论心衰Ⅰ号长期治疗CHF患者安全有效。
- 心衰Ⅰ号 /
- 益气养阴 /
- 活血化痰 /
- 慢性收缩性心力衰竭 /
- 疗效
Abstract: OBECTIVE To observe and evaluate the curative effects of XinshuaiⅠwith the function of replenishing qi and nourishing yin， activating blood circulation and resolving phlegm on chronic systolic heart failure (CHF). METHODS 120 cases with CHF were randomized into treatment group (60 cases) and control group (60 cases). The treatment group were given XinshuaiⅠadministration on the basis of western medicine treatment， 1 package per day for twice use; the control group given XinshuaiⅠplacebo， 1 package per day for twice use， 4 weeks as 1 treatment course， 6 treatment courses as the observation period. The changes of symptoms， life quality score， brain natriuretic peptide (BNP)， left ventricular ejection fraction (LVEF)， 6min walking test (6MWT) and comprehensive effects of 2 groups were compared. RESULTS Significant difference of the symptoms， comprehensive effects， BNP， LVEF， 6MWT appeared before and after the treatment (P<0.05). The overall response rate of the treatment group is 67.24% while that of the control group is 45.61% and the treatment group was better than the control group(P<0.05). During the treatment period， no adverse reaction appeared in both 2 groups. CONCLUSION XinshuaiⅠis safe and effective for the long-term treatment of CHF.
- XinshuaiⅠ /
- replenish qi and nourish yin /
- activate blood circulation and resolve phlegm /
- chronic systolic heart failure (CHF) /
- curative effects

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参考文献(13)

[1]	Cowie MR，Mosterd A，Wood DA，et al.The epidemiology of heart failure[J].Eur Heart J，1999，18:208-225.
[2]	张子彬.充血性心力衰竭[M].北京:科学技术文献出版社，2002: 3，221-222，211.
[3]	Zhang ZB. Congestive heart failure[M]. Beijing: Science & technical documentation press， 2002:3，221-222，211.
[4]	中药新药临床研究指导原则（试行）[S].北京：中国医药科技出版社，2004:77-85.
[5]	〖JP2〗Chinese medicine new drugs clinical research guiding principles (for trial) [S]. Beijing: China medical science press，2004:77-85.〖JP〗
[6]	中华医学会心血管病学分会，中华心血管病杂志编辑委员会.慢性收缩性心力衰竭治疗建议[J].中华心血管病杂志，2002，3（1）：10-30.
[7]	Association of Chinese medicine branch department of professional committee of heart and blood vessel disease. Suggestions on the treatment of chronic heart failure[J]. Chin J Cardiol，2002，3(1):10-30.
[8]	朱波，李七一，司晓晨，等.心衰1号配方颗粒剂对慢性心力衰竭大鼠血流动力学的影响[J].南京中医药大学学报，2009，25(3)：202-204.
[9]	Zhu B， Li QY， Si XC， et al. Effects of XinshuaiⅠgranule on hemodynamics of rats with chronic heart failure[J]. J Nanjing Univ Chin Med， 2009，25(3):202-204.
[10]	宋立人.现代中药学大辞典[M].北京：人民卫生出版社，2001:181，952，1872，2238，1791.
[11]	Song LR. Modern Chinese materia medica dictionary[M]. Beijing: People's medical publishing house， 2001:181，952，1872，2238，1791.
[12]	赵国平.中药大辞典[M].上海:上海科学技术出版社，2006:2522.
[13]	Zhao GP. Chinese medicine dictionary[M].Shanghai: Shanghai science & technology press， 2006:2522.