Abstract: OBJECTIVE To observe the effects of Jiawei Fushen Tang on diabetic nephropathy rats with renal lesions and discuss the possible mechanism. METHODS 40 male SD rats were treated with intraperitoneal injection of STZ+CFA to establish diabetic model after normal feeding for 1 weeks. After successful modeling， the rats were divided into model group (M)， JWFST (L1) group，JWFST (L2) group，JWFST(L3) group. L1， L2， L3 group were treated with JWFST 8g/(kg·d)，16g/(kg·d)， 32g/(kg·d); the model group was given normal saline; the normal control group (C) was 8 male SD rats with conventional feeding. The blood sugar on a regular basis for 8 weeks were recorded. After the experiment， collect 24h urine， the serum was collected and biochemical parameters， like SCr， BUN， SOD， MDA， UPwere detected. Then the kidneys were harvested and the expressions of nephrin and podocin in the kidney were detected by IF method and qPCR method. And then observed the renal lesions under light microscope. RESULTS Compared with the model group， the INS， SCr， BUN， MDA， UP of treatment groups were significantly decreased， and SOD was increased significantly. The expressions of nephrin and podocin were raised significantly by JiaWeiFuShenTang. CONCLUSION JiaWeiFuShenTang can significantly improve the renal damage of DN rats， and delay the development of diabetic nephropathy.