骨癌痛动物模型及在中医药研究中的应用

王长明; 于光; 孟怡倩; 唐宗湘

骨癌痛动物模型及在中医药研究中的应用

南京中医药大学基础医学院，江苏南京 210023

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出版历程
- 收稿日期: 2014-12-26
- 修回日期: 2015-01-26
- 刊出日期: 2015-03-10

Animal Model of Bone Cancer Pain and Its Application in the Study of Traditional Chinese Medicine

摘要

摘要: 骨癌痛是一种严重的癌症痛，其产生机制目前并不清楚。能反映人类骨癌痛特性的动物模型建立对骨癌痛的研究具有重要意义。本文综述了近年来骨癌痛动物模型建立的研究历史，模型动物、肿瘤细胞、手术部位、检测手段的选择，以及在中医药研究中的应用，为不同的实验目的选择不同类型的骨癌痛动物模型提供参考。
- 骨癌痛 /
- 动物模型 /
- 中医药
- bone cancer pain /
- animal model /
- traditional Chinese medicine

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参考文献(46)

[1]	Mantyh PW. Cancer pain and its impact on diagnosis， survival and quality of Life[J]. Nat Rev Neurosci， 2006， 7(10): 797-809.
[2]	King T， Vardanyan A， Majuta L， et al. Morphine treatment accelerates sarcoma-induced bone pain， bone loss， and spontaneous fracture in amurine model of bone cancer[J]. Pain， 2007: 154-168.
[3]	Kjonnik sen I， Winder en M， Bruland O， et al. Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats[J]. Cancer Res， 1994， 54: 1715-1719.
[4]	Schwei MJ， Honore P， Rogers SD， et al. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain[J]. Journal Neurosci， 1999， 19(24): 10886-10897.
[5]	Medhurst SJ， Walker K， Bowes M， et al. A rat model of bone cancer pain. Pain[J]， 2002， 96(1/2)：129.
[6]	Zhang RX， Liu B， Wang LB， et al. Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia[J]. Pain， 2005， 118(1/2): 125-136.
[7]	Cossigny D， Quan GM. In vivo animal models of spinal metastasis[J]. Cancer Metast Rev， 2012， 31(1/2): 99-108.
[8]	Mao-Ying QL， Zhao J， Dong ZQ， et al. A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells[J]. Biochem Biophys Res Commun， 2006， 345(4): 1292-1298.
[9]	Lan LS， Ping YJ， Na WL， et al. Down-regulation of Toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model[J]. Mol Pain， 2010， 6: 2.
[10]	Tong W， Wang W， Huang J， et al. Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain[J]. Biochem Biophys Res Commun， 2010， 395(4): 572-576.
[11]	Hang LH， Yang JP， Yin W， et al. Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats[J]. Eur J Neurosci， 2012， 36(1): 2107-2117.
[12]	Hu S， Mao-Ying QL， Wang J， et al. Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines[J]. J Neuroinflamm， 2012，9:278.
[13]	Xu Q， Zhang XM， Duan KZ， et al. Peripheral TGF-beta 1 Signaling Is a Critical Event in Bone Cancer-Induced Hyperalgesia in Rodents[J]. J Neurosci， 2013， 33(49): 19099-19111.
[14]	Guan XH，Fu QC， Shi D， et al. Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats[J]. Exp Neurol， 2015， 263: 39-49.
[15]	Medhurst SJ， Walker K， Bowes M， et al. A rat model of bone cancer pain[J]. Pain， 2002， 96(1/2): 129-140.
[16]	Fox A， Medhurst S， Courade JP， et al. Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat[J]. Pain， 2004， 107(1/2): 33-40.
[17]	Urch CE， Donovan-Rodriguez T， Gordon-Williams R， et al. Efficacy of chronic morphine in a rat model of cancer-induced bone pain: Behavior and in dorsal Horn pathophysiology[J]. J Pain， 2005， 6(12): 837-845.
[18]	Zheng Q， Fang D， Liu M， et al. Suppression of KCNQ/M(Kv7)Potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model[J]. Pain， 2013， 154(3): 434-448.
[19]	Donovan-Rodriguez T， Dickenson AH， Urch CE. Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain[J]. Anesthesiology， 2005， 102(1): 132-140.
[20]	Dore-Savard L， Otis V， Belleville K， et al. Behavioral， medical imaging and histopathological features of a new rat model of bone cancer pain[J]. PLoS One， 2010， 5(10): e13774.
[21]	Otis V， Sarret P， Gendron L. Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience， 2011， 183: 221-229.
[22]	Ducourneau VR， Dolique T， Hachem-Delaunay S， et al. Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers[J]. Pain， 2014， 155(2): 275-291.
[23]	Li Y， Cai J， Han Y， et al. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain[J]. Eur J Pain， 2014， 18(6): 774-784.
[24]	Wacnik PW， Eikmeier LJ， Ruggles TR， et al. Functional interactions between tumor and peripheral nerve: Morphology， algogen identification， and behavioral characterization of a new murine model of cancer pain[J]. J Neurosci， 2001， 21(23): 9355-9366.
[25]	Furuse S， Kawamata T， Yamamot J， et al. Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal Horn of the spinal cord in a murine model of bone cancer pain[J]. Anesthesiology， 2009， 111(1): 173-186.
[26]	黄东，黄晓玲，阎雪彬，等．C57BL/6小鼠骨癌痛模型的制备与评价[J]．中南大学学报:医学版，2008， 33（2）：115-120．
[27]	Huang D， Huang XL， Yan XB， et al. Establishment and evaluation of a bone cancer pain model[J]. J Centr South Univ: Med Edit， 2008， 33(2): 115-120.
[28]	白桦，李忠，陈维武，等．运用Lewis肺癌细胞系制备小鼠股骨癌痛模型的研究[J]．中华肿瘤防治杂志，2009， 16（14）：1062-1065．
[29]	Bai H， Li Z， Chen WW， et al. Lewis lung cancer cell lines was prepared for studies with femoral cancer pain model[J]. Chin J Cancer Prevent Treat， 2009， 16(14): 1062-1065.
[30]	Isono M， Hosono K， Suzuki T， et al. Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice[J]. J Pharmacol Sci， 2011， 115(1): 254P.
[31]	Seong J， Park HC， Kim J， et al. Radiation-induced alteration of pain-related signals in an animal model with bone invasion from cancer[J]. Ann N Y Acad Sci， 2004， 1030:179-186.
[32]	Park HC， Seong J， An JH， et al. Alteration of cancer pain-related signals by radiation: Proteomic analysis in an animal model with cancer bone invasion[J]. Int J Radiat Oncol Biol Phys， 2005， 61(5): 1523-1534.
[33]	Zhang RX， Li AH， Liu B， et al. Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model[J]. Anesth Analg， 2007， 105(5): 1482-1488.
[34]	Zhang RX， Li A， Liu B， et al. Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model[J]. Eur J Pain， 2008， 12(7): 870-878.
[35]	Zhang R， Lao L. A new rat model of bone cancer pain[J]. Methods Mol Biol， 2012， 851: 261-73.
[36]	De Ciantis PD， Yashpal K， Henry J， et al. Characterization of a rat model of metastatic prostate cancer bone pain[J]. J Pain Res， 2010， 3:213-221.
[37]	Currie GL， Delaney A， Bennett MI， et al. Animal models of bone cancer pain: Systematic review and meta-analyses[J]. Pain， 2013， 154(6): 917-926.
[38]	Yu S， Peng HD， Ju DW， et al. Mechanisms of treatment of cancer pain with a topical Chinese herbal formula in rats[J]. Chin Med J (Engl)， 2009， 122(17): 2027-2031.
[39]	Deng B， Jia LQ， Gao FY， et al. Effect of sangu decoction(SGD)on metastatic bone destruction in rats with mammary cancer[J]. Chin J Integr Med， 2012， 18(4): 304-307.
[40]	Wang JY， Zhang RX， Dong CS， et al. Topical treatment with Tong-Luo-San-Jie gel alleviates bone cancer pain in rats[J]. J Ethnopharmacol， 2012， 143(3): 905-913.
[41]	姜涌，王文萍．中药止痛巴布贴对骨癌痛大鼠痛行为及脊髓背角c-fos表达的影响[J]．中华中医药学刊，2012， 30（5）：964-967．
[42]	Jiang Y， Wang WP. The effects of Chinese medicine Ba Bu Zhi Tong Tie on bone cancer pain behavior and the expression rat c-fos in spinal dorsal Horn in rat[J]. Chin Arch Tradit Chin Med， 2012， 30(5): 964-967.
[43]	杜俊英，陈宜恬，吴赛飞，等．电针治疗大鼠骨癌痛镇痛后效应的参数筛选[J]．中华中医药杂志，2014， 29（5）：1454-1458．
[44]	Du JY，Chen YT， Wu SF， et al. The parameter screening of analgesia after electrical acupuncture on bone cancer pain in rats[J]. China J Tradit Chin Med Pharm， 2014， 29(5): 1454-1458.
[45]	赵志正，刘杰，林洪生．中医药治疗癌性疼痛研究进展[J]．世界中医药，2014， 9（7）：851-856．
[46]	Zhao ZZ， Liu J， Lin HS. Research progress of treating cancer pain with Chinese medicine[J]. World Chin Med， 2014， 9(7): 851-856.