姜黄色素聚电解质纳米粒大鼠体内药动学研究

杨柳; 刘桂花; 宋珏; 王璇; 平其能; 肖衍宇; 张灿

姜黄色素聚电解质纳米粒大鼠体内药动学研究

杨柳¹,
刘桂花¹,
宋珏¹,
王璇¹,
平其能¹,
肖衍宇^1,,
张灿^1,2,

1.
中国药科大学天然药物活性组分与药效国家重点实验室，江苏南京 210009
2.
中国药科大学新药研究中心，江苏南京 210009

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出版历程
- 收稿日期: 2014-06-12
- 修回日期: 2014-08-01
- 刊出日期: 2014-09-10

Pharmacokinetics of Curcuminoids-loaded Polyelectrolyte Nanoparticles in Rats

1.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China
2.
Center of Drug Discovery, China Pharmaceutical University, Nanjing, 210009, China

摘要

摘要: 目的研究姜黄色素聚电解质纳米粒（CUR-PENPs）经大鼠尾静脉注射后的体内药代动力学。方法通过静电吸附法制备CUR-PENPs并对其表征；以姜黄色素（CUR）溶液为对照，研究大鼠尾静脉注射CUR-PENPs的体内药动学。结果透射电镜观察CUR-PENPs呈较规则类球体，平均粒径为(243.0±1.1)nm，Zeta电位为(-28.13±1.41)mV，载药量为5.5%。大鼠尾静脉注射CUR-PENPs的血药浓度-时间曲线下面积（AUC）为CUR溶液3.3倍，血浆清除率（CL）降为CUR溶液的27.8%。结论 CUR-PENPs能相对延长CUR体内滞留时间，提高药物AUC。
- 聚电解质纳米粒 /
- 姜黄色素 /
- 药动学
Abstract: OBJECTIVE To investigate the pharmacokinetical process of curcuminoids-loaded polyelectrolyte nanoparticles (CUR-PENPs) by i.v. administration in rats. METHODS CUR-PENPs were prepared and characterized. The rats were administrated through tail vein with curcuminoids (CUR) solution and CUR-PENPs. RESULTS CUR-PENPs were quasi-spherical shapes observed by TEM. The mean particle size， Zeta potential and drug loading were (243.0 ± 1.1)nm， (-28.13 ± 1.41)mV and 5.5%， respectively. After i.v. administration the area under concentration-time curve (AUC) of CUR-PENPs were 3.30-fold higher than those of CUR solution， the clearance (CL) of CUR-PENPs were 27.8% that of CUR solution. CONCLUSION The results indicate that CUR-PENPs may extend the retention time of CUR and improve the AUC when compared with CUR solution.
- polyelectrolyte nanoparticles /
- curcuminoids /
- pharmacokinetics

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参考文献(6)

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