狼疮静颗粒治疗活动性狼疮性肾炎肾虚湿毒证疗效观察
Therapeutic Effect of Langchuangjing Granule in Treatment of Syndrome of Kidney Deficiency with Damp Toxin in Active Lupus Nephritis
-
摘要: 目的观察中药狼疮静颗粒对活动性狼疮性肾炎（LN）肾虚湿毒证的临床疗效。方法符合入组条件的LN患者共40例，治疗组22例（西药治疗加狼疮静颗粒）．对照组18例（单纯西药治疗），疗程12周，观察治疗前后24h尿蛋白定量（Upr）、尿沉渣红细胞计数（URBC）、血尿素氮（Bun）、血肌酐（Scr）、SLEDAI积分及肾虚湿毒证主要证候的变化，以及治疗期间西药的副作用.结果治疗组对蛋白尿〈3．5g／24h的患者在d8以后减少蛋白尿的作用较好，减轻血尿、降低SLEDAI积分的作用于第4周即表现出明显的优势，组间比较有统计学意义（P〈0．05），并对肾功能有一定的改善，同时治疗组较对照组能更好地缓解皮肤红斑、腰酸痛症状（P〈0．05），减少激素所致的心悸、手抖等副作用（P〈0．05）。结论在西药免疫抑制治疗的基础上配合使用中药狼疮静颗粒，有助于控制狼疮的病情活动、缓解临床症状、减少西药的副作用，对减少蛋白尿、减轻血尿、改善肾功能有较好的促进作用，Abstract: OBJECTIVE To observe the effect of the Chinese drug Langchuangjing Granule in the treatment of the syndrome of kidney deficiency with damp toxin in patients with active lupus nephritis(LN).METHOD Forty LN patients were divided into a treatment group of 22 patients(treated with western medicine and Langchuangjing Granule) and a control group of 18 patients(treated with western medicine only) and were treated for 12 weeks.RESULT Good effect was obtained in relieving albuminuria in the patients with a level of <3.5g/24 h after the 8th day,and hematuria and SLEDAI integral started to be reduced markedly since the 4th week,with statistical significance between the two groups(P<0.05).Kidney function was improved.Better effect was obtained in the treatment group in relieving skin red patches,lumbago,palpitation caused by hormone and tremor of the hand (P<0.05).CONCLUSION Based on the immunity inhibition treatment with western medicine,Langchuangjing Granule is effective in controlling the condition of LN,relieving the clinical symptoms,reducing the side effect of western medicines,relieving albuminuria and hematuria,and improving the kidney function.
-
[1] Cheigh JS,Kim H.Systemic lupus erythematosus in paitents with end-stage renal disease:Long-term follow-up on the prognosis of patients and the evolution of lupus activity[J].Am J Kidney Dis,1990,16:189. [2] Hochberg MC.Updating the American College of Rheumatologyrevised criteria for the classification of SLE[J].Arthritis Rheum,1997,40:1725. [3] Claire Bombardier,Dafna D.Giadman,Murray B.Umwitz et al.Derivation f the SLEDAI[J].Arthrotis and Rheumatism,1997,35(6):630. [4] 邹万忠.肾脏病理与临床[M].长沙:湖南科学技术出版社,1997.55. [5] 郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002.219. [6] 沈庆法.中医临床肾脏病学[M].上海:上海科学技术文献出版社,1997.452. [7] 中国中西医结合肾病专业委员会.弥漫增生型狼疮肾炎中西医结合诊治标准[S].中国中西医结合肾病杂志,2002,3(4):189. [8] 盛梅笑,王钢,王胜菊.狼疮性肾炎中医证候学特征的临床回顾性分析[J].辽宁中医杂志,2004,31(6):475. [9] 王敏,董怡,黄尚东.肿瘤坏死因子α基因多态性及其与系统性红斑狼疮的相关性[J].中华内科杂志,1999,38(3):393. [10] 蔡后荣,张杏书,刘布骏,等.血清可溶性IL-2R检测在结缔组织病中的应用[J].上海免疫学杂志,1993,13(4):216. [11] 杨利,金实,汪悦,等.狼疮静颗粒对活动性SLE患者血清sIL-2R、TNF-α的影响[J].中国中医药信息杂志,2000,7(9):37. -
点击查看大图
计量
- 文章访问数: 1315
- HTML全文浏览量: 20
- PDF下载量: 0
- 被引次数: 0
下载:
