The Influence of Qianyang Yuyin Granules on Acute Cerabral Infarction Patients in Blood Pressure Variability and Short-Term Nerve Functional Recovery

OBJETIVE To discuss the influence of Qianyang Yuyin granules on acute cerabral infarction patients in high blood pressure， blood pressure variability (BPV) and short-term nerve functional recovery. METHODS 80 acute cerebral infarction patients accompanied by yin deficiency and yang hyperactivity predominant high blood pressure were enrolled and divided into the treatment group and the control group with 40 each. The control group was given levoamlodipine while the treatment was given Qianyang Yuyin granules as well as levoamlodipine. The course lasted for 12 weeks. Ambulatory blood pressure monitoring (ABPM) was taken to detect patients' ambulatory blood pressure in 24 h before and after administration and BPV was calculated. The scores of NIHSS， Barthel index， yin deficiency and yang hyperactivity syndrome were recorded. RESULTS After treatment， patients in the treatment group had significantly lower mean systolic pressure and diastolic pressure in 24 h and the daytime， respectively (P<0.01). Compared with the control group， systolic pressure and diastolic pressure in the daytime decreased more in the treatment group (P<0.05). Patients' 24 h BPV decreased significantly (P<0.05，P<0.01) and that in the treatment group decreased more obviously in each period (P<0.05，P<0.01). The scores of NIHSS， Barthel index in two groups were better than those before treatment (P<0.05，P<0.01) and the treatment group were better (P<0.05). As for yin deficiency and yang hyperactivity syndrome， it was relieved significantly in the treatment group with lower score than that before treatment (P<0.05，P<0.01)， which was much lower than that of the control group (P<0.05，P<0.01). The rates of aggravation and recurrence in the treatment group were much lower than those in the control group (P<0.05). CONCLUSION Qianyang Yuyin granules can effectively improve traditional Chinese medicine syndrome for patients with yin deficiency and yang hyperactivity predominant acute cerebral infarction accompanied by hypertension， resulting in lowering BPV and promoting the recovery for nerve function.