Effects of Liguzinediol on Hemodynamics in Chronic Heart Failure Rats Induced by Doxorubicin

OBJECTIVE To explore the effect of Liguzinediol on cardiac function， ventricular remodeling and inflammation in chronic heart failure (CHF) rat model induced by doxorubicin (Dox). METHODS The hemodynamic changes in the maximum ascending/descending rate of left ventricular pressure (+dp/dt_max)， left ventricular pressure (LVSP)， arterial systolic pressure (ASP)， arterial diastolic pressure (ADP) and heart rate (HR) were recorded by multichannel physiological recorder with intragastric administration of Liguzinediol in CHF rats induced by Dox (intraperitoneal injection， 2 mg/kg). The effects of Liguzinediol on oxygen free radicals (NO， NOS， SOD， MDA) and inflammatory factors (IL-6 and TNF-α) were also detected by the kits. RESULTS Liguzinediol increased the levels of LVSP， +dp/dt_max， ASP， ADP， AP and HR， and decreased the level of -dp/dt_max(P<0.05，P<0.01). Liguzinediol decreased the concentration of NO， iNOS and MDA ， increased the activity of SOD， and inhibited the contents of IL-6 and TNF-α(P<0.05，P<0.01). CONCLUSION Liguzinediol can improve ventricular remodeling by reducing the release of inflammatory factors， inhibiting the formation of oxygen free radicals.