HU Yong, MOU Hai-jun, CHEN Ke. Clinical Effect Observation of Jianpishugan and Huoxuehuatan Formula on Liver Depression and Spleen Deficiency Induced Non-Alcoholic Steatohepatitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(4): 359-362.
Citation: HU Yong, MOU Hai-jun, CHEN Ke. Clinical Effect Observation of Jianpishugan and Huoxuehuatan Formula on Liver Depression and Spleen Deficiency Induced Non-Alcoholic Steatohepatitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(4): 359-362.

Clinical Effect Observation of Jianpishugan and Huoxuehuatan Formula on Liver Depression and Spleen Deficiency Induced Non-Alcoholic Steatohepatitis

More Information
  • Received Date: March 31, 2017
  • Revised Date: June 01, 2017
  • OBJECTIVE To study the clinical effect of Jianpishugan and Huoxuehuatan formula on liver depression and spleen deficiency induced non-alcoholic steatohepatitis. METHODS 140 patients with liver depression and spleen deficiency induced non-alcoholic steatohepatitis admitted in our hospital from Oct. 2015 to Oct. 2016 were selected and randomly divided into the observation group and the control group according to the random number. Both groups were given exercise and diet therapy, and the control group was also treated with polyene phosphatidylcholine capsules. Based on the control group, the observation group was also treated with modified Jianpishugan and Huoxuehuatan Formula. RESULTS Symptom scores and the total scores of the clinical symptoms in two groups decreased significantly (P<0.01) after the treatment, but that in the observation group decreased more significantly (P<0.01). Total effective rate of overall efficacy in the observation group was 94.28% after the treatment, which was significantly higher than that in the control group (77.14%, P<0.01). Total effective rate of TCM syndrome in the observation group was 95.71% after the treatment, which was significantly higher than that in the control group (77.14%, P<0.01). ALT, AST and GGT levels in two groups decreased significantly (P<0.01) after the treatment, but that in the observation group decreased more significantly (P<0.01). Abdominal B ultrasound results in two groups improved significantly after the treatment(P<0.01), but that in the observation group improved more significantly (P<0.01). During the treatment, patients in two groups did not complain of other discomforts, adverse reactions and toxic effects. CONCLUSION Jianpishugan and Huoxuehuatan Formula can noticeably improve the clinical symptoms and liver functions of patients with liver depression and spleen deficiency induced non-alcoholic steatohepatitis.
  • [1]
    王唯坚, 胡唆. 155例非酒精性脂肪肝患者的中医证候学研究[J]. 首都医科大学学报, 2014, 35(1): 129-131.
    [2]
    WANG WJ, HU S. The traditional Chinese medical syndrome study on 155 patients with non-alcoholic fatty liver disease[J]. J Cap Univ Med Sci, 2014, 35(1): 129-131.
    [3]
    陈祈玲.台湾非酒精性脂肪肝病之流行病学[J]. 临床肝胆病杂志, 2010, 26(2):144-146.
    [4]
    CHEN QL. Epidemiology of nonalcoholic fatty liver disease in Taiwan[J]. J Clin Hepatol, 2010, 26(2): 144-146.
    [5]
    任路平,宋光耀.非酒精性脂肪肝疾病发生机制研究新进展[J].中国老年学杂志,2012, 32(3):664-666.
    [6]
    REN LP, SONG GY. Research progress of occurrence mechanism of non-alcoholic fatty liver disease[J]. Chin J Gerontol, 2012, 32(3): 664-666.
    [7]
    中华医学会肝病学分会脂肪肝和酒精性肝病专业委员会. 非酒精性脂肪性肝病诊疗指南[S]. 药品评价,2007,4(2): 77-79.
    [8]
    Chinese Society of Hepatology, Fatty Liver and Alcoholic Liver Disease, Specialized Committee. Guidelines for Diagnosis and Treatment of Nonalcoholic Fatty Liver Diseases[S]. Drug Eval, 2007, 4(2): 77-79.
    [9]
    中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:86-89.
    [10]
    Guideline for Clinical Trials of New Patent Chinese Medicines[M]. Beijing: China medical science and technology press, 2002: 86-89.
    [11]
    冯高飞, 陈若. 疏肝健脾方治疗肝郁脾虚型非酒精性脂肪性肝炎40例[J]. 中医研究, 2015, 28(10):5-6.
    [12]
    FENG GF, CHEN R. Shugan Jianpi Formula in the treatment 40 cases of liver depression and spleen deficiency induced non-alcoholic steatohepatitis[J]. Res Chin Med, 2015, 28(10): 56.
    [13]
    陈峰.逍遥散加减治疗肝郁脾虚型非酒精性脂肪性肝炎 33 例[J]. 福建中医药, 2010, 41(3): 43-44.
    [14]
    CHEN F. Modified Xiaoyao Powder in the treatment of 33 cases of liver depression and spleen deficiency induced non-alcoholic steatohepatitis[J]. Fujian Chin Med, 2010, 41(3): 43-44.
    [15]
    王雁翔,王灵台, 高月求,等.脂肪肝中医证型流行病学调查及其中医病因病机初探[J]. 中国中西医结合杂志,2005, 25(2): 129.
    [16]
    WANG YX, WANG LT, GAO YQ, et al. Epidemic survey on TCM syndrome typing and preliminary discussion on TCM etiology and pathogenesis of fatty liver[J]. Chin J Integr Trad West Med, 2005, 25(2): 129.

Catalog

    Article Metrics

    Article views (1179) PDF downloads (1102) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return