Clinical Study of Self-Made Enriching Yin and Subduing Yang， Regulating Liver and Extinguishing Wind Formula in the Treatment of Tourette Syndrome Caused by Wind Stirring due to Yin Deficiency

OBJECTIVE To study the clinical effectiveness and influence of Enriching Yin and Subduing Yang， Regulating Liver and Extinguishing Wind Formula in the treatment of Tourette syndrome caused by wind stirring due to yin deficiency. METHODS 80 patients with Tourette syndrome caused by wind stirring due to yin deficiency admitted in our hospital from Oct. 2013 to Oct. 2016 were selected and randomly divided into the observation group and the control group by random number， 40 cases in each group. The control group was treated with inosine combined with vitamin B6， and the observation group was treated with self-made Enriching Yin and Subduing Yang， Regulating Liver and Extinguishing Wind Formula. One month for a course for both groups， and both were treated for 3 courses. Changes of clinical symptoms and signs were observed before and after treatment. YGTSS of American Infant Psychosis Study Institute was applied to test the YGTSS scores in two groups before and after treatment. The clinical effect was evaluated according to the reduction rate of YGTSS scale. Cellular immunity (CD3+， CD4+， CD8+ and CD4+/CD8+) and humoral immunity (serum IgG， IgA and IgM) levels in two groups were tested. Patients in two groups were followed up for 3 months to count the recurrence. RESULTS Total scores of TCM syndrome in two groups decreased significantly (P<0.01) after treatment， but that in the observation group decreased more significantly (P<0.01). Motor tics， incidence tics， resultant damages and YGTSS scores of total in two groups decreased significantly (P<0.01) after treatment， but that in the observation group decreased more significantly (P<0.01).Total effective rate in the observation group was 97.5%， which was significantly higher than that in the control group (85.0%， P<0.05). The recurrence rate of the observation group (5%) significantly lower than that in the control group (20.00%)(P<0.05). CD3+， CD4+， CD8+ and CD4+/CD8+ in two groups improved significantly after treatment (P<0.01)， but that in the observation group improved more significantly (P<0.01). IgA， IgG and IgM levels in two groups increased significantly after treatment (P<0.01)， but that in the observation group increased more significantly (P<0.01). CONCLUSION Enriching Yin and Subduing Yang， Regulating Liver and Extinguishing Wind Formula can significantly improve clinical symptoms of patients with Tourette syndrome， decrease patients， incidence tics， motor tics and resultant damages， which have significant clinical effectiveness and high safety. Its action mechanism may be related to the improvement of immunity.