Effect of Zuowu Decoction on the Outcome of Poor Ovarian Response Patients with IVF/ICSI-ET

OBJECTIVE To evaluate the impact of Zuowu decoction on ovarian response and pregnancy related indicators of poor ovarian response (POR) patients with in vitro fertilization/ intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). METHODS 100 patients with POR due to deficiency of kidney-essence and spleen-qi were randomly divided into the treatment group and the control group with 50 cases in each. Both groups received routine IVF/ICSI-ET while the treatment group was pre-administrated with Zuowu Decoction for 3 months， and then given IVF/ICSI-ET. The dosage and administration duration of gonadotropin (Gn)， the levels of estradiol (E₂) and progesterone (P) on human chorionic gonadotropin(HCG) trigger day， number of retrieved oocytes， high-quality embryo rates， biochemical pregnancy rate， clinical pregnancy rate and ongoing pregnancy rate were compared between the two groups. RESULTS The differences of the following indicators were no statistically significant: the dosage and administration duration of Gn， the level of E₂ and P on HCG trigger day， high-quality embryo rates and biochemical pregnancy rate (P>0.05). The number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in the treatment group were all higher than those in the control group (P<0.05). CONCLUSION Zuowu Decoction can increase the number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in POR patients with IVF/ICSI-ET treatment.