Experimental Research into Tounong Powder Preventing Formation of Chronic Peptic Ulcer Scar

OBJECTIVE To investigate Tounong Powder's optimizing fibroblast's function and preventing the formation of chronic peptic ulcer scar through its effect on the content of growth hormone (GH)， hydroxyproline (Hyp) and hyaluronidase (HAase).METHODS Acid burning chronic gastric ulcer model was established. The rats were divided into 8 groups: blank control group， model group， high， middle and low-dose of Tounong Powder groups， western medicine control groups (omeprazole group， ranitidine group and Hydrotalcite group). ELISA was applied to detect the GH， Hyp and HAase levels. RESULTS 14 days after administration， compared with model group， GH levels of all the Tounong Powder groups decreased， while HAase increased. Hyp of high-dose group went up， but in low and middle-dose groups it was reduced.CONCLUSION Tounong Powder lowers GH and Hyp levels and elevates HAase level， thereby optimizing fibroblast function to prevent chronic gastric ulcer scar shaped. Its effect in some respects is better than the control.