Experimental Study on Jinxin Oral Liquid Different Chemical Components Oppressing Respiratory Syncytial Virus

OBJECTIVE To observe the effect of Jinxin Oral Liquid (JOL) different chemical components on respiratory syncytial virus (RSV).METHODS The mice pneumonia models were set up through nasal drops with RSV， which were randomly divided into normal control group， model control group， ribavirin group， JOL group， petroleum ether extract group， ethyl acetate extract group， N-butanol extract group and mother liquor group. The condition of the inflammatory lesion in lung tissues was observed under light microscope. Pulmonary index and pulmonary index inhibition rate， spleen index， thymus index and death protection rate were calculated.RESULTS Petroleum ether extract， ethyl acetate extract and n-butanol extract of JOL remarkably decreased pulmonary index of mice infected with RSV (P<0.01) and reduced the inflammatory lesions in lung tissues; meanwhile， increased spleen index and thymus index (P<0.01). N-butanol extract of JOL reduced the death rate of mice infected with RSV. CONCLUSION Petroleum ether extract， ethyl acetate extract and n-butanol extract of JOL have a certain inhibitory effect on RSV， and can improve the immune function of mice infected with RSV. N-butanol extract of JOL can make certain death protection for mice with RSV.