Effects of Basil Capsules on Expressions of VEGF and Bcl-2 for Transplanted Liver Cancer in rats after TACE

OBJECTIVE To observe the effects of Basil capsules on expressions of VEGF and Bcl-2 for transplanted liver cancer in rats after transcatheter arterial chemoembolization (TACE) and to research the influence and significance of Basil capsules on hypoxia environment after TACE of rats hepatoma.METHODS Transplanted hepatoma models of rats were established. Ten days later， the successful models were divided into five groups randomly. The group with TACE and saline (A)，group with TACE and high-dose Basil capsules (B)， group with TACE and moderate-dose Basil capsules (C)，group with TACE and low-dose Basil capsules (D) were injected with 10 mL/kg/d saline， 300 mg/kg/d/ Luole capsule， 150 mg/kg/d Basil capsule and 75 mg/kg/d Basil capsules respectively. The fifth group (E) as control group was operated just with laparotomy. After ten days of administration， the pathological specimen of transplanted liver cancer was taken out and the expressions of VEGF and Bcl-2 in tumor tissues were detected through immunohistochemistry.RESULTS As for the tumor weight， group A， B， C and D were obviously smaller than that of group E (P<0.01，P<0.05); group B was remarkably lighter than that of group A (P<0.05). As for the positive expression rate of VEGF and Bcl-2， both group A and E obviously increased (P<0.01)；groups B， C and D visibly deceased compared with that of group A(P<0.01); groups B was remarkably lower than those of groups D and E (P<0.01，P<0.05). CONCLUSION Basil capsules can improve hypoxia environment in the local part of rat hepatoma， promote cell apoptosis， depress the expression of VEGF and Bcl-2 and inhibit the invasion and metastasis of tumor after TACE.