Clinical Research on XinshuaiⅠfor Chronic Systolic Heart Failure

OBECTIVE To observe and evaluate the curative effects of XinshuaiⅠwith the function of replenishing qi and nourishing yin， activating blood circulation and resolving phlegm on chronic systolic heart failure (CHF). METHODS 120 cases with CHF were randomized into treatment group (60 cases) and control group (60 cases). The treatment group were given XinshuaiⅠadministration on the basis of western medicine treatment， 1 package per day for twice use; the control group given XinshuaiⅠplacebo， 1 package per day for twice use， 4 weeks as 1 treatment course， 6 treatment courses as the observation period. The changes of symptoms， life quality score， brain natriuretic peptide (BNP)， left ventricular ejection fraction (LVEF)， 6min walking test (6MWT) and comprehensive effects of 2 groups were compared. RESULTS Significant difference of the symptoms， comprehensive effects， BNP， LVEF， 6MWT appeared before and after the treatment (P<0.05). The overall response rate of the treatment group is 67.24% while that of the control group is 45.61% and the treatment group was better than the control group(P<0.05). During the treatment period， no adverse reaction appeared in both 2 groups. CONCLUSION XinshuaiⅠis safe and effective for the long-term treatment of CHF.