Effect of Lizhi Sanjie Pill on Levels of Estrogen and Progestin of Hysteromyoma Patients

OBJECTIVE To observe the effect of Lizhi Sanjie Pill on the levels of estrogen (ER) and progestin (PR) of hys teromyoma patients. METHOD Immunohistochemical method was used to detect ER and PR levels of hysteromyoma and myometrium of 15 patients who had taken exclusively Lizhi Sanjie Pill for three months and had received surgery, compared with another 15 patients who had not taken the pill but also had received surgery. RESULT The ER and PR levels of hysteromyoma were higher than those of myometrium ( P < 0.05) and the ER and PR levels in the control group were markedly higher than those in the treatment group (P< 0. 05). CONCLUSION The reduction of the ER and PR levels is probably one of the main mechanisms of Lizhi Sanjie Pill in the treatment of hysteromyoma.