Volume 21 Issue 2
Mar.  2005
Turn off MathJax
Article Contents
Abstract
References
SUN Min, SUN Jing, ZHU Quan. Effect of Chinese Drugs with Anti-oxidation Function on Protein Non-enzyme Glycosylation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2005, 21(2): 103-105.
Citation: SUN Min, SUN Jing, ZHU Quan. Effect of Chinese Drugs with Anti-oxidation Function on Protein Non-enzyme Glycosylation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2005, 21(2): 103-105.
shu

Effect of Chinese Drugs with Anti-oxidation Function on Protein Non-enzyme Glycosylation

More Information
  • Revised Date: November 19, 2004
    Graphical Abstract
    • Abstract
  • OBJECTIVE To observe the effect of Picrorhiza rhizome and Hypericum perforatum on in vitro protein non-enzyme glycosylation, evaluate the relationship between the anti-oxidation effect and non-enzyme glycosylation, and analyze the possibility of their use in the treatment of diabetes. METHOD BSA and glucose were used to produce an in vitro system for non-enzyme glycosylation, and the reaction fluid was divided into a control group and groups with different concentration, which were incubated for 60 days. The fluorescent value of each groups were then determined. RESULT The two drugs with different concentrations could markedly and dose-dependently inhibit the formation of AGEs. CONCLUSION The two drugs can inhibit the protein non-enzyme glycosylation, which is probably related to their anti-oxidation function.
    • FullText(HTML)
    • References (19)
  • [1]
    吴凤兰 张亚非.硒和维生素E对糖尿病大鼠氧化和非酶糖化的影响[J].营养学报,1999,21(2):172-176,.
    [2]
    陈志武 章家胜.金丝桃甙对大鼠脑梗塞的保护作用[J].中国中药杂志,1998,23(10):626-628,.
    [3]
    项光亚 郝巧玲.金丝桃清除活性氧作用研究[J].广东药学院学报,2000,16(4):282-284,.
    [4]
    项光亚 周宜开.化学发光法检测金丝桃对DNA的损伤的保护作用[J].同济医科大学学报,2000,29(3):209-211,.
    [5]
    朱健如 王晓团 等.贯叶连翘提取物在延缓衰老作用的研究[J].华中科技大学学报：医学版,2002,31(6):659-661,665.
    [6]
    移文 刘建文 魏东芝.对PC12神经细胞损伤的保护作用[J].中国临床药理学与治疗学,2003,8(1):27.
    [7]
    Brownlee M. Glycation and diabetic complications [J]. Diabetes, 1994,43: 836.
    [8]
    Torjesten R. Advanced glycation end products in serum predict in the kidney morphology of patients with insulin-dependent mellitus [J]. Mrtablism, 1997,46: 661.
    [9]
    Asgary S, Naderi G, Sarrafzadegan N , et al . Antioxidant effect of flavonoids on hemoglobin glycosylation[J]. Pharm Acta Helv, 1999,73 (5):223.
    [10]
    Nagasawa T , Tabata N , Ito Y, et al . Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative[J]. Mol Cell Biochem,2003,249(122) :3.
    [11]
    Horiuchi S , Araki N , Morino Y. Immunochemical approach to character ize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure[J]. J Biol Chem,1991,266 (12) :7329.
    [12]
    Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and their interaction with AGEs receptors in vascular disease and diabetes mellitus Ⅰ . The AGE concept[J]. Cardiovasc Res, 1998,37 (3):586.
    [13]
    Munch G, Keis R , Wessels A,et al. Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA [J]. Eur J Clin Chem Clin Biochem, 1997,35 (9) :669.
    [14]
    Brownlee M. Advanced protein glycosylatlon in diabetes and aging[J]. Annu Rev Med, 1995,46: 223.
    [15]
    Chen HJ, Cerami A. Mechanism of inhibition of advanced glycosylation by aminoguanidine in vitro[J]. J Carbohydr Chem,1993,12: 732.
    [16]
    Vlassara H. Pathogenic effects of advanced glycosylation:Biochemical, biologic, and clinical implications for diabetes and aging[J]. Lab Invest, 1994,70:138.
    [17]
    Simons JM, Hart BA, Ip Vai Ching TR, et al. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils[J]. Free Radic Biol Med, 1990,8:251.
    [18]
    Chander R, Singh K, Viscn PK, et al. Picroliv prevents oxidation in serum lipoprotein lipids of Mastomys coucha infected with Plasmodium berghei[J]. Indian J Exp Biol, 1998,36:371.
    [19]
    Hao W, Yang S, Wen-Cai Y, et al. Antioxidative phenylethanoid and phenolic Glycosides from picrorhiza scrophulariiflora[J] .Chem Pharm Bull. 2004, 52(5) : 615.
    • Related Articles

Catalog

    Get Citation
    XML

    Article Metrics

    Article views (1122) PDF downloads (0) Cited by()
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return