Abstract: OBJECTIVE To explore the curative effect of curcumin microemulsion gel on skin fibrosis after radiotherapy and the effect for fibrosis index factors. METHODS 80 patients with skin fibrosis diagnosed after tumor radiotherapy from March 2017 to December 2018 in the Department of Oncology of Affiliated Hospital of Nanjing university of Chinese medicine were selected. Curcumin microemulsion gel was set as the treatment group and asiaticoside cream was set as the control group， with 2 times daily skin administration for 2 consecutive months. The total effective rate， western medicine score， traditional Chinese medicine (TCM) syndrome score and expression of fibrosis factor in the two groups were compared. RESULTS After treatment， the total effective rate of the treatment group was 92.5%， better than 77.5% in the control group(P<0.05). Two groups of western medicine treatment efficacy scores were significantly improved (P<0.05). The treatment group was significantly better than the control group in improving the arthralgia (P<0.05). 2 groups of TCM syndrome evaluations were improved (P<0.05). The skin of the treatment group was hard and the symptoms of limb numbness were better than those of the control group (P<0.05). The serum fibrinization factor hydroxyproline (HYP)， transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) of the two groups all decreased significantly (P<0.01). The contents of TGF-β and CTGF in blood serum of treatment group were significantly lower than those of control group (P<0.05). CONCLUSION Curcumin microemulsion gel treatment has significant effects on skin fibrosis after radiotherapy， and reduces the levels of fibrosis factor in patients' blood significantly.