Abstract: OBJECTIVE To discuss the influence of the rehabilitation formula for banking up earth to generate metal on COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage in terms of clinical efficacy and immunology-related indexes. METHODS 120 COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage were divided into the treatment group (89 cases) and the control group (31 cases). The rehabilitation formula for banking up earth to generate metal was given to the treatment group while the control group was not given any interventions. The course was 14 days. The symptom scores were observed before and after treatment in the two groups and the effective rates in the two groups were compared. RESULTS The effective rate of the treatment group was 94.38%， higher than 54.84% in the control group (P<0.01). The symptom scores before and after treatment in group A and B had no significant differences (P>0.05)， and so did the effective rate (P>0.05). The levels of IgA， Complement C3 after the treatment group were lower than those before treatment (P<0.01). The percentages of CD3， CD4 and CD8 were higher after the treatment group than those before (P<0.01). Compared with those in the control group， the percentages of CD3 and CD4 in the treatment group had significant difference(P<0.05). CONCLUSION The rehabilitation formula for banking up earth to generate metal can effectively improve the clinical symptoms caused by deficiency of lung and spleen for COVID-19 patients in the recovery stage as well as their immunologic function.