Abstract: Huayu Sanjie is one of the important principles of anti-tumor in clinical Chinese medicine. From the dialectical of blood stasis syndrome， the use of activating blood and removing phlegm drugs， especially the traditional Chinese medicine compound based on blood-breaking drugs， which is used to treat tumors through Huayu Sanjie makes a good result. There is controversy about whether blood-breaking drugs have anti-tumor effects. At present， clinical studies have found that blood-breaking drugs may promote tumor metastasis， but most basic studies have shown that blood-breaking drugs can resist tumor metastasis. The purpose of this paper is to determine the anti-tumor and tumor metastasis effects of blood-breaking drugs by combining modern medical theories， and further propose the potential molecule mechanism of this effect， that is， blood-breaking drugs may interfere with the aerobic glycolysis process of tumors，and inhibit tumor growth and metastasis. In this paper， the anti-tumor and tumor metastasis molecule mechanism of blood-breaking drugs was studied for the first time from the energy metabolism process of glycolysis， which provided a new idea for the anti-tumor and anti-metastatic research of blood-breaking drugs， and provides a basis for the anti-tumor application of clinical blood-breaking drugs.