Abstract: OBJECTIVE To observe the therapeutic effect of Da Aiduan warm needle moxibustion on allergic rhinitis with cold of deficiency pattern in lung qi and explore its mechanism. METHODS The selected cases were randomly divided into the observation group (105 cases) and the control group (105 cases). The observation group was treated with Da Aiduan warm needle moxibustion once a day， four times a week， four weeks as a course. In the control group， patients were given fluticasone propionate nasal spray and orally taken desloratadine citrate disodium tablets in acute phase， Fu Shu Liang alone when patients were in stable condition. The course was four weeks. At the end of treatment and 30 days after treatment， the changes of total syndrome scores， physical sign points， visual analogy score (VAS)， serum immunoglobulin E (IgE)， interleukin 4 (IL-4)， γ interferon (IFN-γ) were observed. RESULTS The total symptom scores， physical sign points and VAS of nasal symptoms severity in the two groups were significantly lower than those before treatment (P<0.01)， and the observation group was significantly lower than that in the control group (P<0.05， P<0.01). The three indexes of serum were statistically significant both within and between groups (P<0.01). Follow-up result (30 days after treatment) indicated that the curative effect of the observation group was better than that of the control group (P<0.05). The total symptom scores， physical sign points and VAS of nasal symptoms severity in the two groups were significantly lower than that before treatment (P<0.01) and the observation group was significantly lower than that in the control group (P<0.05，P<0.01). The given indexes of the two groups before treatment and 30 days after treatment were monitored. It showed that there was no significant difference in the changes of three indexes of serum and IFN-γ in the control group (P>0.05). When it came to the comparison of three indexes in the observation group and between the two groups， they had significant difference (P<0.01). CONCLUSION The Da Aiduan warm needle moxibustion has good therapeutic effect on allergic rhinitis patients with cold of deficiency pattern in lung qi. It can significantly improve the clinical symptoms， physical signs and VAS score of the patients， with better effect in regulating the content of serum IgE， IL-4 and IFN-γ than the control group. Its mechanism may be related to the decrease of serum IgE， IL4 and the increase of IFN-γ.