Abstract: OBJECTIVE To systematically evaluate the clinical effect of Danshen injection and Shenmai injection in the treatment of coronary heart disease. METHODS Searching the Cochrane Library， Wanfang data resource system， Medline database， full text Database of Chinese Sci-tech Journals (VIP) and the Database of China Knowledge Network (CNKI)， all randomized controlled clinical trials of Danshen injection (control group) and Shenmai injection (experimental group) in the treatment of coronary heart disease were included. The literature screening， data extraction and quality evaluation were carried out according to Cochrane Handbook evaluation standard. RevMan 5.3 software was used to carry on the Meta analysis to the included research. RESULTS A total of 1 211 articles were searched and 20 RCTs were included in this study， involving 2 034 patients. Meta-analysis showed that Shenmai injection group significantly improved the clinical symptoms and ECG manifestations of coronary heart disease (RR=1.22， 95%CI:1.16~1.28， I²=0%， P≤0.80) compared with Danshen injection group. No adverse reactions were reported. CONCLUSION Shenmai Injection is more effective than Danshen injection in the treatment of coronary heart disease.