Abstract: OBJECTIVE To discuss Zhang Jian-zhai's therapy characteristics and medication feature in the treatment of miscellaneous disease due to internal injury based on Zhang Jian-zhai's Case Records. METHODS The clauses of therapy for internal diseases in Zhang Jian-zhai's Case Records was summarized. Then APRIORI association rules and binomial test were applied to conduct data mining， analysis on those therapeutic methods so as to disclose Zhang's medication feature. RESULTS On the summary of the therapy recorded in Zhang Jian-zhai's Case Records， it has been found that there were four most commonly applied therapeutic methods， that is， dredging， harmonizing， clearing and strengthening， which applied Chinese medicine with relevant properties. It also showed us the most commonly prescribed Chinese medicine， like gan cao (glycyrrhiza uralensis)， bai shao (paeoniae alba)， ban xia (pinelliae tuber) and fu shen (sclerotium poriae pararadicis). As for the highly used couplet medicinals and formulae， they were mainly prescribed based on the combination of these four herbs. CONCLUSION In terms of the four commonly applied therapeutic methods to treat miscellaneous disease due to internal injury， dredging method was to release the exterior pathogen， dispel the inner dampness， rectify qi and harmonize stomach so as to resolve the obstruction. Harmonizing method highlighted the role of calming mind in addition to reconciling yin and yang. Clearing method was to clear lung heat， dissolve phlegm and calm heart. Strengthening method was to diffuse the exterior by nourishing the interior. On the whole， Mr Zhang's medication feature tended to be mild， which aimed at regulating zang-fu organs. Furthermore， fu shen was applied in three of the four therapeutic methods， which implicated Zhang's clinical thinking of emphasizing the regulation of heart spirit.