Abstract: OBJECTIVE To observe the effect of Chinese herbal compound Qingshen capsule on chronic kidney failure patients' kidney function， serum α-smooth muscle actin (α-SMA)and E-cadherin. METHODS 70 chronic kidney failure patients with dampness-heat syndrome were randomly divided into the treatment group and the control group with35 in each. Based on the therapy for the control group， the treatment group was also given Qingshen capsule. The course lasted 12 weeks. After that， 68 patients completed the follow-up， each group 34 cases. The observing parameters included curative effect of traditional Chinese medicine (TCM) syndrome， clinical effect， the level of serum creatinine (Scr)，e-GFR serum α-SMA and E-cadherin before and after treatment. RESULTS After treatment， TCM syndrome effect and clinical effect of the treatment group was better than that of the control group (P<0.05). As for the level of Scr and eGFR， patients in the treatment group has much improved (P<0.05) than those in the control group (P<0.05). The level of serum α-SMA and E-cadherin declined (P<0.05)， lower than that of control group (P<0.05). Patients in the treatment group hadn't been exposed to the side effects of Qingshen capsule. CONCLUSION Qingshen capsule can relive clinical symptoms for chronic kidney failure patients with dampness-heat syndrome， more precisely， degrading Scr level， serum α-SMA and E-cadherin and having good safety.