Abstract: Recurrent allergic disease is an inevitable clinical challenge. Yupingfeng San (YPFS) clinically shows unique advantages in the prevention and treatment of allergic diseases， however its mechanism has not been fully elucidated. Based on the traditional Chinese medicine treatment strategy "Yiqi Gubiao"， our research group explored the effects and mechanisms of YPFS in the treatment of allergic diseases and anti-allergic recurrence. We confirmed its unique advantages in treating of allergic diseases， especially anti-allergic relapse. The main active components of YPFS were screened by cell binding combined with HPLC-MS and serum pharmacology. The active components and their potential targets were predicted and analyzed by network pharmacology. From the perspective of regulating and maintaining immune homeostasis as well as repairing epithelial barrier function， the scientific connotation of "Yiqi Gubiao" was further explored and understood.