Abstract: OBJECTIVE To study the prediction effect of TCM physical personality and constitution on the risks of MD complicated with CHD. METHODS TCM physical personality and constitution of 110 T2MD patients were tested by five pattern personality inventor and five-five constitution. CHAID model of decision tree in EXCEL and SPSS was used to establish disease risk model of MD complicated with CHD predicted by TCM personality and constitution types. And the prediction accuracy of the model was evaluated. RESULTS Tested by cross validation， the prediction accuracy of MD disease model established with the Shao-yin personality， Yin-cold constitution and blood-stasis constitution as the predictor variables was relatively higher (93.6%)， and three rules for predicting CHD risk were obtained. CONCLUSIONS The prediction rules of the MD complicated with CHD by TCM personality and constitution are consistent with the traditional understanding of Chinese medicine， which provides a reference for high-risk population's early screening， CHD prevention and treatment， clinical differentiation and treatment.