Abstract: OBJECTIVE To study the mechanism of loganin， the effective componet of Cornus officinalis， on protecting the glomerulus mesangial cell (GMCs) injured by advanced glycation end products (AGEs). METHODS GMCs were divided into control， model (AGEs: 200mg/L)， loganin (0.1， 1， 10μmol/L) groups. The cell proliferation， FN and COL-Ⅳ secretion， microstructure lesions， RAGE， SphK1， S1P and TGF-β protein expressions were measured. RESULTS AGEs induced cell proliferation， FN and COL-Ⅳ secretions， microstructure lesions， RAGE， SphK1， S1P and TGF-β protein expressions were suppressed by loganin. CONCLUSION Loganin can improve the AGEs induced GMCs injury by regulating the AGEs/RAGE/SphK1 signal pathway， and then ameliorate the diabetic nephropathy.