Abstract: OBJECTIVE To observe the clinical effect of moxibustion on acupoint Feishu (BL13) in the treatment of acute asthma in children (cold-asthma)， and to provide clinical evidence for treatment of asthma with acupuncture and moxibustion. METHODS 87 children with asthma (cold-asthma) who meet the inclusion criteria were selected and randomly divided into 2 groups. The control group was treated with conventional western medicine， and the observation group was treated with moxibustion on bilateral Feihu Points(BL13) on the basis of routine western medicine. CRP， IgE， IL1， IL6， EOS， pulmonary function and symptom score were selected as observation indexes for the clinical effects comparison of patients in two groups. RESULTS Indexes levels such as CRP， IgE， IL6 and EOS in the observation group were significantly lower than that in the control group after treatment (P<0.05~0.01). FEV1 and PEF levels of patients in the observation group were significantly better than that in the control group after treatment (P<0.05). Symptom score in the observation group was significantly lower than that in the control group after treatment (P<0.05). Apparent rate (73.81%) of patients in the observation group was significantly higher than that in the control group (53.33%) (P<0.05). CONCLUSION Moxibustion on acupoint Feishu in the treatment of acute asthma in children (cold-asthma) can markedly decrease the levels of CRP， IgE， IL6 and EOS in patients， improve pulmonary function， and can achieve remarkable clinical curative effect.