健脾疏肝活血化痰方治疗肝郁脾虚型非酒精性脂肪性肝炎的临床疗效观察
Clinical Effect Observation of Jianpishugan and Huoxuehuatan Formula on Liver Depression and Spleen Deficiency Induced Non-Alcoholic Steatohepatitis
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摘要: 目的 探讨健脾疏肝活血化痰方治疗肝郁脾虚型非酒精性脂肪性肝炎的临床疗效。方法 选取2015年10月-2016年10月我院收治的140例非酒精性脂肪性肝炎且中医辨证分型为肝郁脾虚型患者，将其按照随机数字法随机分为观察组和对照组，2组均给予运动、饮食治疗，对照组在此基础上给予多烯磷脂酰胆碱胶囊，观察组在对照组基础上给予健脾疏肝活血化痰方加减治疗。结果 治疗后2组症状积分及临床症状总积分均显著下降（P<0.01)，但观察组下降更为明显（P<0.01)。 治疗后观察组总体疗效总有效率为94.28%，显著高于对照组(77.14%，P<0.01）。治疗后观察组中医证候总有效率为95.71%，显著高于对照组（77.14%，P<0.01）。治疗后2组ALT、AST、GGT水平均显著下降（P<0.01)，但观察组下降更为明显（P<0.01)。治疗后2组腹部B超情况均显著改善（P<0.01)，但观察组改善更为明显（P<0.01)。治疗期间2组患者未诉其他不适及不良反应和毒副作用。结论 健脾疏肝活血化痰方可显著改善肝郁脾虚型非酒精性脂肪性肝炎患者的临床症状和肝功能。Abstract: OBJECTIVE To study the clinical effect of Jianpishugan and Huoxuehuatan formula on liver depression and spleen deficiency induced non-alcoholic steatohepatitis. METHODS 140 patients with liver depression and spleen deficiency induced non-alcoholic steatohepatitis admitted in our hospital from Oct. 2015 to Oct. 2016 were selected and randomly divided into the observation group and the control group according to the random number. Both groups were given exercise and diet therapy， and the control group was also treated with polyene phosphatidylcholine capsules. Based on the control group， the observation group was also treated with modified Jianpishugan and Huoxuehuatan Formula. RESULTS Symptom scores and the total scores of the clinical symptoms in two groups decreased significantly (P<0.01) after the treatment， but that in the observation group decreased more significantly (P<0.01). Total effective rate of overall efficacy in the observation group was 94.28% after the treatment， which was significantly higher than that in the control group (77.14%， P<0.01). Total effective rate of TCM syndrome in the observation group was 95.71% after the treatment， which was significantly higher than that in the control group (77.14%， P<0.01). ALT， AST and GGT levels in two groups decreased significantly (P<0.01) after the treatment， but that in the observation group decreased more significantly (P<0.01). Abdominal B ultrasound results in two groups improved significantly after the treatment(P<0.01)， but that in the observation group improved more significantly (P<0.01). During the treatment， patients in two groups did not complain of other discomforts， adverse reactions and toxic effects. CONCLUSION Jianpishugan and Huoxuehuatan Formula can noticeably improve the clinical symptoms and liver functions of patients with liver depression and spleen deficiency induced non-alcoholic steatohepatitis.
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