Abstract: OBJECTIVE To evaluate the clinical efficacy of Zishen Qinggan Formula through observing its effects on arterial function and inflammatory factors in patients with essential hypertension. METHODS 100 essential hypertension patients who meet the inclusion criteria were selected and randomly divided into the treatment group and the control group， 50 cases in each group. The treatment group received ACEI/ARB+CCB standard treatment combined with Zishen Qinggan Formula， and the control group received ACEI/ARB+CCB drugs treatment. The course of treatment was 8 weeks. Changes of TCM syndrome scores， carotid intima-media thickness， UltraFast imaging pulse wave velocity (PWV)， resistance index， inflammatory factors and safety indexes were compared before and after treatment. RESULTS ①TCM syndrome scores in both groups improved significantly after treatment， and that in the treatment group was better than the control group(P<0.01). ② UltraFast imaging PWV of bilateral carotid arteries and resistance indexes in both groups improved after treatment (P<0.01)， among which the treatment group was better than the control group(P<0.05). IMT of bilateral carotid arteries had no difference in two groups before and after treatment (P>0.05). ③ Levels of serum CRP， IL6 and TNFα in both group improved after treatment (P<0.05)， and that in the treatment group were better than the control group(P<0.01) ④ There was no significant difference in liver and kidney function in two groups before and after treatment(P>0.05). CONCLUSION In the aspect of improvement of arterial elasticity and inflammatory factors in patients with essential hypertension， western medicine ACEI/ARB+CCB basic therapy combined with Zishen Qinggan Formula is better than ACEI/ARB+CCB basic therapy alone.