Abstract: OBJECTIVE To observe the differences of curative effect among superficial needle therapy， Xiakucao oral solution and Vitamin E soft capsules on the breast tenderness caused by mammary glands hyperplasia and to explore the optimum therapeutic method. METHODS 105 patients with mammary glands hyperplasia were randomly divided into the superficial needling group， the Xiakucao group and the Vitamin E group， with 35 cases in every group. Patients in the superficial needling group were treated with the superficial needling retaining for 5 hours. Patients in the Xiakucao group and the Vitamin E group took medicine with oral administration. Treatment in the three groups all began from 7±3 days before menstruation and stopped during menstruation. The superficial needling group was treated once every other day with total 3 times. Patients in the Xiakucao group took medicine twice a day in the morning and evening. The Vitamin E group was treated once a day. Compare the scores of short form McGill pain Questionnaire (SF-MPQ) before and after the treatment and after one month follow-up. Record the time needed for pain relieving in the first treatment of the superficial needling group and the adverse effects in the three groups. RESULTS After the treatment， the breast tenderness was improved obviously in the three groups (P<0.01) and the superficial needling group was superior to the other groups (P<0.01). During the one-month follow up， the superficial needling group showed good effects (P<0.01). It also showed fast effect on relieving the pain in the first treatment. The Xiakucao group was superior to the Vitamin E group in the improvement of the breast tenderness (P<0.05). CONCLUSION The superficial needling therapy shows fast and lasting effects on relieving the pain of mammary glands hyperplasia， which is superior to Xiakucao oral solution and Vitamin E soft capsules.