Abstract: OBJECTIVE To observe the treating effect of Huobahuagen tablets in intervening diabetic nephropathy in clinical stage and the influence on the level of serum HGF. METHODS DN patients in clinical stage were divided into two groups: the treatment group(Huobahuagen tablets together with Irbesartan capsules) and the control group(Irbesartan capsules)， with 30 cases in each group. The control group was given Irbesartan capsule (150 mg) every day in the morning for once and the patients took it with an empty stomach. The treatment group， besides taking the same medicine as prescribed for the control group， was also given Huobahuagen tablets， 3 tablets a day for three times 0.5h after each meal. FPG， 2 hPG， HbA1c， TG， TC， LDL-C， HDL-C， blood SCr， urine ACR， UTP， HGF level were tested. RESULTS ACR， UTP， SBP， DBP， blood fat， and SCr in both groups decreased after the treatment (P<0.05~0.01) and the decrease in the treatment group was sharper than that in the control group (P<0.05~0.01). The total effective rate in the treatment group was better in the treatment group (83.3% vs 40%，P<0.01). HGF levels in both group increased after the treatment (P<0.01). HGF level in the treatment group showed more increase compared with that of the control group (P<0.01). CONCLUSION Huobahuagen tablets can effectively lower the level of blood creatinine and the rate of urinary albumin excretion， increase the level of serum HGF， and possibly slow down DN progression.