Abstract: OBJECTIVE To observe the clinical effect of Qianyang Yuyin granules treating early renal damage patients with yin deficiency and yang hyperactivity type hypertension. METHODS 60 elderly early renal damage patients with yin deficiency and yang hyperactivity type hypertension were randomly divided into two groups: the control group (30 cases) and the observation group (30 cases). In the control group， western medicine amlodipine (or combined with valsartan) was given to reduce blood pressure. The observation group wasn't given Qianyang Yuyin granules until the reduced hypertension adhered to the standard on the basis of those medications used in the control group. 24 weeks later， in addition to comparing the clinical efficacy of the two groups， the research also compared the changes of the early renal damage indexes: glomerular filtration rate (GFR) detected by single photon emission computed tomography (SPECT)， cystatin C (Cyst-C)， urinary β₂ microglobulin (β₂-MG)， urine N-acetyl-β-D glycosidase (NAG) and so forth. RESULTS After treatment， the effective rates of the observation group and the control group were 96% and 50% successively， of which differences were significant (P<0.01). The levels of the early renal damage indexes， Cyst-C and β₂-MG， in the two groups were significantly improved (P<0.05)， and the improvement effect in the observation group was more significant than that in the control group (P<0.05). The renal damage indexes (GFR， NAG) in the observation group were significantly improved (P<0.05)， and were superior to that in the control group (P< 0.05). CONCLUSION Qianyang Yuyin granules can effectively reduce the early renal damage for hypertension patients on the basis of the reduced hypertension adhering to the standard and improve the clinical symptoms.