Abstract: OBJECTIVE To study the effects of diet fawu on allergic contact dermatitis (ACD) in mice models and to explore the possible mechanism. METHODS Mice models of ACD was established and the effects of mutton， bamboo shoots， yellow wine， green pepper， sea shrimp on inflammatory reaction and related cytokines was observed respectively at 48 h after elicitation. RESULTS Compared with the control group， mutton， yellow wine， green pepper groups can significantly increase the ear swelling and the number of infiltrating inflammator cells in mice models（P<0.05）， bamboo shoots， sea shrimp groups showed no significant difference (P>0.05). The ear weight changes of each group except mutton showed no significant difference compared with the control group (P>0.05); mutton， yellow wine， green pepper groups can markedly increase expression level of IFN- γ， IL-17， IL-2 in peripheral blood (P<0.05)， bamboo shoots group decreased (P<0.05)， no significant effect of shrimp group (P>0.05). CONCLUSION Mutton， green peppers， yellow wine can aggravate ACD in mice possibly by up-regulation the expressions of IFN-γ， IL-17， IL-2. Bamboo shoots and sea shrimp have no effect on mice ACD.