Abstract: OBJECTIVE To observe the effect of Yunpiqiangsheng Fang on improving quality of life (QOL) of peritoneal dialysis (PD) patients. METHODS 55 patients were divided into treatment group (26) and control group (29). Control group received western medicine and conventional PD treatment apart from which treatment group was added Yunpiqiangsheng Fang as well for three months. After the treatment， changes in KDQOL-SFTM1.3 scale score， nutrition indicators (Hb， Alb， pre-A， TSF， MAC， MAMC， MQSGA)， metabolic parameters (TC， TG， Ca²⁺， P³⁺， PTH) and dialysis-related indicators (BUN， Scr， KT / V， Ccr) were observed. RESULTS ① Treatment group can increase KDQOL-SFTM1.3 scale score with total effective rate 83.3 %， superior to control group (P<0.01) especially in improving the symptoms， health condition and sleep， relieving the impact of kidney disease for life， and enhancing strengh(P<0.05). ② After treatment， MQSGA in treatment group significantly decreased (P<0.01) while Hb， Alb， pre-A， TSF increased (P<0.05) compared with that before treatment. The changes of MQSGA， Hb， pre-A， TSF are better than that of control group (P<0.05). ③ There is no statistically significant difference in TC， TG， Ca²⁺， P³⁺， PTH among the groups (P>0.05). ④ BUN in treatment group is decreased (P<0.05) whose change is larger than that of control group (P<0.05). There is no statistically significant difference in Scr，KT/V，Ccr among the groups (P>0.05). CONCLUSION Yunpiqiangsheng Fang can help improve PD patients' QOL， which plays an important role in increasing appetite， enhancing digestion and absorption， regulating overall function of organs， thereby improving patients' nutrition.