Abstract: OBJECTIVE To study the influence of asthma-reliving decoction on pulmonary function and Clara cell secretion protein (CC16) of children with asthma. METHODS 120 children with asthma were randomly divided into control group (60 case) and treatment group (60 cases). Each group was first received with Seretide inhalation therapy. Treatment group were given with asthma-reliving decoction additionally. After 3 courses， the therapy effect was evaluated. And then， the pulmonary function index (FEV1 and PEF) and the levels of CC16， IgE and eosinophil cationic protein (ECP) were observed before and after the treatment. RESULTS After the treatment， the pulmonary function in treatment group was obviously improved. The level of CC16 increased and IgE and ECP decreased in each group. And ones in treatment group were more effective than that of control group. The clinical efficiency of treatment group was 91.67%， which was obviously higher than that of control group. CONCLUSION The asthma-reliving decoction can improve pulmonary function obviously and shows a certain regulation of CC-16， IgE and ECP， which may play the role of relieving cough and asthma.