定喘汤对哮喘患儿肺功能及CC16的影响
Influence of Asthma-reliving Decoction on Pulmonary Function and Clara Cell Secretion Protein of Children with Asthma
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摘要: 目的 探讨定喘汤对哮喘患儿肺功能及Clara细胞分泌蛋白（CC16）的影响。方法 120例支气管哮喘患儿随机分成对照组和治疗组，每组60例。对照组给予沙美特罗替卡松粉干粉剂吸入治疗，治疗组在此基础上加用定喘汤治疗。3个疗程后，评价临床疗效，并比较患儿肺功能指标（FEV1和PEF）以及CC-16、IgE和嗜酸粒细胞阳离子蛋白（ECP）水平。结果 治疗组患儿FEV1和PEF较对照组有明显改善；2组患儿CC16水平均明显增加，IgE和ECP水平均显著降低，且治疗组对CC16、IgE和ECP的改善程度优于对照组。治疗组临床有效率为91.67%，明显高于对照组（78.33%）。结论 定喘汤能显著改善患儿肺功能，对IgE、ECP和CC16具有一定的调节作用，从而发挥止咳平喘的功效。
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关键词:
- 定喘汤 /
- 哮喘患儿 /
- 肺功能 /
- Clara细胞分泌蛋白
Abstract: OBJECTIVE To study the influence of asthma-reliving decoction on pulmonary function and Clara cell secretion protein (CC16) of children with asthma. METHODS 120 children with asthma were randomly divided into control group (60 case) and treatment group (60 cases). Each group was first received with Seretide inhalation therapy. Treatment group were given with asthma-reliving decoction additionally. After 3 courses， the therapy effect was evaluated. And then， the pulmonary function index (FEV1 and PEF) and the levels of CC16， IgE and eosinophil cationic protein (ECP) were observed before and after the treatment. RESULTS After the treatment， the pulmonary function in treatment group was obviously improved. The level of CC16 increased and IgE and ECP decreased in each group. And ones in treatment group were more effective than that of control group. The clinical efficiency of treatment group was 91.67%， which was obviously higher than that of control group. CONCLUSION The asthma-reliving decoction can improve pulmonary function obviously and shows a certain regulation of CC-16， IgE and ECP， which may play the role of relieving cough and asthma. -
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