Abstract: OBJECTIVE To observe the clinical therapeutic effects of the formula capable of resolving turbidity， removing toxin， activating blood circulation and dredging collectrals in improving patients with vascular cognitive impairment of none dementia(VCIND) after stroke. MEHTODS 128 cases with VCIND after stroke were randomly divided into treatment group and control group， with 64 cases in each group. Patients in the treatment group were given compound Changpu Yizhi Decociton warmly both early in the morning and late in the afternoon， one bag per day. While those in the control group were treated with nimodipine， 30mg at a time， three times per day. Both groups received three-month treatment. TCM syndromes， cognitive ability， activity of daily living before and after treatment were evaluated and the levels of homocysteine and acetylcholinesterase were tested to detect the safety index and side effects. RESULTS There experienced an evident improvement of the treatment group in TCM syndrome curative effects and scores， together with obvious increases in the scores of mini-mental state examination(MMSE) and Activity of Daily Living (ADL)， decreased scores in ADAS-cog and declined levels in homocysteine and acetylcholinesterase when compared to the control group. The difference was statistically significant(P<0.05). Neither evident abnormalities nor side effects were detected before and after treatment in the test. CONCLUSION Compound Changpu Yizhi Decoction can efficiently improve the TCM syndromes， cognitive function and daily living activity and reduce the levels of homocysteine and acetylcholinesterase of patients with VCIND after stroke.