Abstract: OBJECTIVE To investigate into the protecting effect of total iridoid glycoside in Fructus Corni Officinalis on experimental diabetes models with heart disease. METHOD Models were made with high-fat diet and STZ injection.Two weeks later,Jiangtang Tongmai Capsule(0.8 g/kg) and ICO(0.05,0.1,0.2 g/kg) were used in the treatment for 16 weeks. RESULT In the model group,fasting blood sugar of the rats increased,the levels of serum NO and NOS decreased,plasma ET level rose markedly,heart indexes increased(P<0.05,P<0.01),overgrowth of the heart muscle occurred as revealed by optical microscope,varying degrees of matrix edema and tissue cell hyperplasia appeared,and there were mild inflammation and fibrosis in the endocardium and pericardium.After the application of ICO and Jiangtang Tongmai Capsule,the symptoms were relieved.CONCLUSION WT5"BZ ICO has certain protecting effect on diabetes with heart disease.