Abstract: OBJECTIVE To explore into the effect and mechanism of using As_2O_3 nanometer microballoon magnetism induced heating in the treatment of cervical carcinoma. METHOD Athymic mouse transplantation tumor models of human cervical carcinoma was made using SiHa cells.As_2O_3 nanometer microballoons,magnetic nanometer microballoons and As_2O_3 magnetic nanometer microballoons were then infused into the inoculation location of the tumor cells,which were then heated for 3 times with high-frequency alternating magnetic field.The experiment lasted for 45 days. RESULT Under the high-frequency alternating magnetic field,no tumor growth was detected in the As_2O_3 magnetic nanometer microballoon group,the tumor growth inhibiting rate being 99.93%,markedly higher than the As_2O_3 nanometer microballoon group(85.20%,P<0.01) and the magnetic nanometer microballoon group(87.72%,P<0.01).No marked differences were detected between the experimental groups and the control group in serum AST,ALT,Bun and Cr(P>0.05).No marked lesion was found in the tissue around the tumors and internal organs.CONCLUSION Under the high-frequency alternating magnetic field,As_2O_3 nanometer microballoons, magnetic nanometer microballoons and As_2O_3 magnetic nanometer microballoons are all effective in treating cervical carcinoma,especially As_2O_3 magnetic nanometer microballoons.As_2O_3 magnetic nanometer microballoons used in combination with fluid thermotherapy has dual anti-cancer effect.