Abstract: OBJECTIVE To investigate into the effect of carp baked with Radix Astragali seu Hedysari on SOD,GSH-Px,NO and NOS of aging mice and explore into the possibility of health care with medicinal diet.METHOD Aging mice were fed with feedstuff mixed with carp baked with Radix Astragali seu Hedysari for 40 days,followed by determination of various indexes.RESULT In the groups with low and median dosage of carp baked with Radix Astragali seu Hedysari and the groups with median dosage of Radix Astragali seu Hedysari,SOD activity was markedly different from the experimental control group(P<0.05);this difference also existed between the high dosage groups and the experimental control group(P<0.05).In the groups of carp baked with Radix Astragali seu Hedysari,the activity of liver GSH-Px was marked different from the experimental control group(P<0.01).In the groups with low and median dosage of carp baked with Radix Astragali seu Hedysari,test is NO was markedly different from the experimental control group(P<0.05).In the groups with low dosage of carp baked with Radix Astragali seu Hedysari,NOS activity was markedly different from the experimental control group(P<0.05).CONCLUSION The medicinal diet carp baked with Radix Astragali seu Hedysari has certain anti-oxidation effect and can affect NO content and NOS activity of aging mice.Therefore,medicinal diet can be used for health care purposes.