Citation: | ZHOUXue-ping, ZHOULing-ling, ZHUHua-xu, FENGZhe, XIETong, LUYan, WANGJing, FULing. Multi-Dimensional Analysis of the Mechanism ofTripterygium Wilfordii Hook.f. Compound Prescription Based on "Heterogeneous Restriction" in Reducing Hepatotoxicity from the Perspective of Substance-Metabolism-Toxicity Correlation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(6): 795-798. |
[1] |
LI XX, DU FY, LIU HX, et al. Investigation of the active components inTripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity[J]. J Ethnopharmacol, 2015, 162: 238-243.
|
[2] |
JING XP, CHENG WW, GUO S, et al. Toxic effects ofTripterygium wilfordii Hook F on the reproductive system of adolescent male rats[J]. Biomed Pharmacother, 2017, 95: 1338-1345.
|
[3] |
陈一凡, 蔡皓东. 中药引起肝损害的调查分析[J]. 药物不良反应杂志, 1999(1): 27-32.
|
[4] |
顾清, 尤本明, 杨帝顺, 等. 基于纳米乳-凝胶技术的雷公藤多苷纳米载体的制备及药效学研究[J]. 中国中药杂志, 2015, 40(1): 73-78.
|
[5] |
FIDLER JM, AN J, CARTER BZ, et al. Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102[J]. Cancer Chemother Pharmacol, 2014, 73(5): 961-974.
|
[6] |
马致洁, 章从恩, 唐进法, 等. 雷公藤配伍甘草降低肝毒性的代谢通路探讨[J]. 药学学报, 2017, 52(7): 1077-1084.
|
[7] |
任献青, 郑贵珍, 苏杭, 等. 菟丝子黄酮对雷公藤多苷片致生精细胞周期阻滞、凋亡及相关蛋白表达降低的影响[J]. 药物评价研究, 2018, 41(1): 55-60.
|
[8] |
曾又佳, 李顺民. 白藜芦醇拮抗雷公藤甲素卵巢毒性实验研究[J]. 新中医, 2014, 46(8): 172-174.
|
[9] |
周学平, 周玲玲, 王旭. 基于“异类相制”理论探讨中药复方的配伍减毒作用[J]. 中医杂志, 2013, 54(4): 271-273.
|
[10] |
陆艳, 谢彤, 张亚杰, 等. 基于“异类相制”理论的雷公藤复方配伍对CYP450酶系的影响[J]. 中华中医药杂志, 2017, 32(3): 1050-1056.
|
[11] |
FENG Z, ZHOU C, DONG S, et al. Catalpol andPanax notoginseng saponins synergistically alleviate triptolide-induced hepatotoxicity through Nrf2/ARE pathway[J]. Toxicol Vitro, 2019, 56: 141-149.
|
[12] |
ZHOU LL, ZHOU C, FENG Z, et al. Triptolide-induced hepatotoxicity can be alleviated when combined withPanax notoginseng saponins and Catapol[J]. J Ethnopharmacol, 2018, 214: 232-239.
|
[13] |
刘蒙竹, 张新龙, 潘林梅, 等. 清络通痹方中雷公藤配伍减毒的化学基础研究[J]. 中国实验方剂学杂志, 2014, 20(7): 107-112.
|
[14] |
孙龙, 张本永, 朱华旭, 等. 清络通痹精简方中雷公藤“异类相制”减毒机制的化学基础[J]. 中国实验方剂学杂志, 2017, 23(11): 50-54.
|
[15] |
ZHANG BY, ZHANG QC, LIU MZ, et al. Increased involvement ofPanax notoginseng in the mechanism of decreased hepatotoxicity induced byTripterygium wilfordii in rats[J]. J Ethnopharmacol, 2016, 185: 243-254.
|
[16] |
耿姗, 冯哲, 袁呈晨, 等. 雷公藤复方配伍对大鼠肝脏代谢酶基因表达的影响[J]. 中国实验方剂学杂志, 2016, 22(6): 140-144.
|
[17] |
谢彤, 周学平, 林丽丽, 等. 基于“异类相制”的雷公藤复方配伍减毒代谢组学研究[J]. 中国中药杂志, 2016, 41(6): 1124-1129.
|
[18] |
谢彤, 李桓, 陆艳, 等. 基于代谢组学探讨清络通痹方配伍生地黄和三七对雷公藤肝毒性的影响[J]. 中华中医药杂志, 2017, 32(8): 3462-3467.
|
[19] |
XIE T, ZHOU XP, WANG SC, et al. Development and application of a comprehensive lipidomic analysis to investigateTripterygium wilfordii-induced liver injury[J]. Anal Bioanal Chem, 2016, 408(16): 4341-4355.
|
[20] |
LU Y, XIE T,ZHANG Y, et al. Triptolide Induces hepatotoxicity via inhibition of CYP450s in rat liver microsomes[J]. BMC Complement Altern Med, 2017, 17(1): 15.
|
[21] |
LI M, WANG J, FU L, et al. Network pharmacology-based prediction and verification of qingluo tongbi formula to reduce liver toxicity ofTripterygium wilfordii via UGT2B7 in endoplasmicReticulum[J]. Med Sci Monit, 2020, 26: 920376.
|
[22] |
周玲玲, 耿姗, 陆伟, 等. 雷公藤调控核受体CAR-代谢酶引起肝毒性的机制研究[C]//2016年第六届全国药物毒理学年会论文集, 重庆:中国毒理学会: 438-439.
|
[23] |
FU L, ZHOU LL, GENG S, et al. Catalpol coordinately regulates phase Ⅰ and Ⅱ detoxification enzymes of triptolide through CAR and NRF2 pathways to reduce triptolide-induced hepatotoxicity[J]. Biomed Pharmacother, 2020, 129: 110379.
|
[24] |
刘春晖, 周玲玲, 马可迅, 等. 从自噬角度研究雷公藤甲素引起HepG2细胞肝毒性的机制[J]. 中国实验方剂学杂志, 2017, 23(10): 99-103.
|