Volume 36 Issue 4
Jul.  2020
Turn off MathJax
Article Contents
Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2020  >  36(4): 498-503
HE Shan, NING Yan, JIANG Shao-yan, LIU Da-yan, WU Fang-ting, HOU Hai-ruo, DENG Shao-jie. Network Pharmacology Research of Huanglian in Treatment of Polycystic Ovary Syndrome with Hyperandrogenism[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(4): 498-503.
Citation: HE Shan, NING Yan, JIANG Shao-yan, LIU Da-yan, WU Fang-ting, HOU Hai-ruo, DENG Shao-jie. Network Pharmacology Research of Huanglian in Treatment of Polycystic Ovary Syndrome with Hyperandrogenism[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(4): 498-503.
shu

Network Pharmacology Research of Huanglian in Treatment of Polycystic Ovary Syndrome with Hyperandrogenism

  • Publish Date: 2020-07-10
    Abstract
  • OBJECTIVE To explore the material basis and mechanism of Huanglian in the treatment of polycystic ovary syndrome with hyperandrogenism （PCOS-HA） based on network pharmacology. METHODS With the help of TCMSP to collect the compounds and effective targets of Huanglian， the compound-target network was constructed by Cytoscape software， the disease targets of the data screening of GeneCards， OMIM and CTD were collected， and the effective targets of the drug were analyzed by Venny to determine the intersection targets. The target protein interaction network was constructed with String database， and the gene function GO enrichment analysis and KEGG pathway enrichment analysis were carried out by DAVID database. RESULTS 11 active compounds， 111 drug targets， 370 disease targets and 37 intersecting targets were obtained. The PPI network involved 30 protein nodes， with key targets including FOS， JUN， IL-6， MAPK1， NCOA2， CCL2， ESR1. GO functional enrichment analysis was mainly related to positive regulation of transcription， response to drug， transcription initiation from RNA polymerase Ⅱ promoter， aging and so on. 46 KEGG Access were mainly involved TNF signaling pathway and FoxO signaling pathway. CONCLUSION The network pharmacology confirms the multi-component， multi-target and multi-pathway action characteristics of huanglian which predicts the possible mechanism of it in the treatment of PCOS-HA， and provides theoretical basis for further study of the active ingredients and mechanism.

     

    • FullText(HTML)
  • loading
    • References(27)
  • [1]
    GLINTBORG D，HASS RUBIN K，NYBO M，et al．Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome[J]．Eur J Endocrinol，2015，172(5)：627-638．
    [2]
    AZZIZ R，CARMINA E，DEWAILLY D，et al．The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome：The complete task force report[J]．Fertil Steril，2009，91(2)：456-488．
    [3]
    罗前．多囊卵巢综合征伴高雄激素或合并高胰岛素血症患者中医体质及证型的对比研究[D]．成都：成都中医药大学，2017．
    [4]
    国家药典委员会.中华人民共和国药典:一部[S]. 北京:中国医药科技出版社，2015.
    [5]
    郑慧颖，李庆端，蔡雪红，等．黄连素对多囊卵巢综合征大鼠高雄激素状态及StAR蛋白表达的影响[J]．中华中医药杂志，2017，32(9)：4230-4234．
    [6]
    李慕白，高敬书，寇丽辉，等．小檗碱对胰岛素抵抗多囊卵巢综合征患者激素水平的调节作用[J]．中国妇幼保健，2015，30(11)：1718-1720．
    [7]
    HOPKINS AL．Network pharmacology[J]．Nat Biotechnol，2007，25(10)：1110-1111．
    [8]
    张彦琼，李梢．网络药理学与中医药现代研究的若干进展[J]．中国药理学与毒理学杂志，2015，29(6)：883-892．
    [9]
    吴嘉瑞，金燕萍，王凯欢，等．基于网络药理学的“金银花-连翘”药对作用机制分析[J]．中国实验方剂学杂志，2017，23(5)：179-183．
    [10]
    HUANG DW，SHERMAN BT，LEMPICKI RA．Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources[J]．Nat Protoc，2009，4(1)：44-57．
    [11]
    李炜，牛建昭，王继峰，等．槲皮素的植物雌激素作用及其受体机制研究[J]．中国医院药学杂志，2015，35(2)：91-95．
    [12]
    YUAN HQ，YOUNG CY，TIAN YY，et al．Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1，c-Jun，and the androgen receptor in human prostate cancer cells[J]．Mol Cell Biochem，2010，339(1/2)：253-262．
    [13]
    PINGALI S，DONAHUE JP，PAYTON-STEWART F．Tetrahydroberberine，a pharmacologically active naturally occurring alkaloid[J]．Acta Crystallogr C Struct Chem，2015，71(Pt 4)：262-265．
    [14]
    洪娟．四氢小檗碱衍生物的合成与抗炎活性研究[D]．广州：暨南大学，2013．
    [15]
    宁娜．巴马汀降脂活性及作用机理研究[D]．重庆：西南大学，2015．
    [16]
    张爱萍．黄连素对多囊卵巢综合征胰岛素抵抗的影响[J]．中国中医药信息杂志，2013，20(12)：70-71．
    [17]
    苏椿淋，陈敏，徐雯，等. 睾酮对成年C57BL/6雌鼠胰岛素敏感性及持续低度炎症状态的影响[J]. 中华医学杂志，2017，97（1）：47-52.
    [18]
    曹雪涛．医学免疫学[M]．北京：人民卫生出版社，2013：173-175．
    [19]
    康学智，贾丽娜．从中医“痰湿”诸证看TNF-α在多囊卵巢综合征证治中的作用[J]．中华中医药学刊，2017，35(4)：826-829．
    [20]
    夏燕，王惠仔，郑建淮．慢性炎症因子在多囊卵巢综合征中的作用机制[J]．中国实验动物学报，2010，18(5)：414-416．
    [21]
    ESCOBAR-MORREALE HF，CALVO RM，SANCHO J，et al．TNF-alpha and hyperandrogenism：A clinical，biochemical，and molecular genetic study[J]．J Clin Endocrinol Metab，2001，86(8)：3761-3767．
    [22]
    GONZLEZ F，NAIR KS，DANIELS JK，et al．Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women[J]．Am J Physiol Endocrinol Metab，2012，302(3)：E297-E306．
    [23]
    YANG Y，QIAO J，LI R，et al．Is interleukin-18 associated with polycystic ovary syndrome?[J]．Reprod Biol Endocrinol，2011，9：7．
    [24]
    SANCHEZ AM，CANDAU RB，BERNARDI H．FoxO transcription factors：Their roles in the maintenance of skeletal muscle homeostasis[J]．Cell Mol Life Sci，2014，71(9)：1657-1671．
    [25]
    贺婷婷，刘昕，刘洪彬，等．多囊卵巢综合征患者颗粒细胞叉头框蛋白O1 mRNA的表达与意义[J]．山东大学学报(医学版)，2019，57(2)：75-79．
    [26]
    彭利红，李泽军，陈敏，等．一种多信息融合的药物-靶标关联预测算法[J]．计算机工程，2016，42(6)：218-223，229．
    [27]
    丁劲，张耀圣，商建伟. 五子衍宗丸治疗男性不育症的网络药理学探讨[J]. 中国实验方剂学杂志，2019，25(20)，25-35.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (645) PDF downloads(451) Cited by()
    Proportional views
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return