Volume 36 Issue 4
Jul.  2020
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Article Navigation >  Journal of Nanjing University of traditional Chinese Medicine  > 2020  >  36(4): 494-497
JIAYue-jun, ZUOWen-ren, SUXue-lin, TANGJing-yuan, HEYao-shu, WANGShi-yan, SUJian, ZHOUEn-chao, ZHUQing-yi. Protective Effect and Mechanism of Compound Yishen Jiedu Decoction on Acute Renal Ischemia-Reperfusion Injury in Rats[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(4): 494-497.
Citation: JIAYue-jun, ZUOWen-ren, SUXue-lin, TANGJing-yuan, HEYao-shu, WANGShi-yan, SUJian, ZHOUEn-chao, ZHUQing-yi. Protective Effect and Mechanism of Compound Yishen Jiedu Decoction on Acute Renal Ischemia-Reperfusion Injury in Rats[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(4): 494-497.
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Protective Effect and Mechanism of Compound Yishen Jiedu Decoction on Acute Renal Ischemia-Reperfusion Injury in Rats

  • 1.

    Department of Urology Surgery, Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, 212000, China

  • 2.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China

  • Publish Date: 2020-07-10
    Abstract
  • OBJECTIVE To investigate the protective effect and mechanism of compound Yishen Jiedu decoction on acute renal ischemia-reperfusion injury in rats. METHODS 48 male rats were randomly divided into four groups: sham surgery group， renal ischemia-reperfusion group (RIR group)， Yishen jiedu decoction plus renal ischemia-reperfusion group (Drug+RIR group)， and curcumin plus renal ischemia-reperfusion group (Cur+RIR group). Blood samples were collected from the fundus vein at 24 h and 96 h after surgery to compare the serum levels of creatinine （Scr） and urea nitrogen （BUN） in each group. The renal tissues were collected 24 h after surgery， and the renal injury scores of each group were compared. NF-κB levels in Sham surgery group， RIR group and Drug+RIR group were compared. RESULTS Compared with the sham surgery group， serum Scr， BUN， and renal tubular injury scores in RIR group， Drug+RIR group and Cur+RIR group were all increased. Serum Scr， BUN and renal injury scores of the Drug+RIR group were higher than those of the Cur+RIR group， but were significantly lower than those of the RIR group (P<0.05). And compared the serum Scr and BUN of 96h affer surgery， the renal function of the Drug+RIR group recovered faster than RIR group. CONCLUSION Compound Yishen Jiedu decoction has obvious protective effect on renal ischemia-reperfusion injury in rats， and its mechanism may be related to NF-κB related inflammatory factors.

     

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    • References(14)
  • [1]
    ZHENG Y，LU M，MA LL，et al．Osthole ameliorates renal ischemia-reperfusion injury in rats[J]．J Surg Res，2013，183(1)：347-354．
    [2]
    杨少勇.丙泊酚保护肾脏缺血再灌注损伤的分子机制研究[D]．天津：天津医科大学，2013．
    [3]
    束洋，周恩超．“益肾解毒汤”联合中药长程间歇灌肠治疗慢性肾脏病3~4期30例临床研究[J]．江苏中医药，2015，47(11)：29-31．
    [4]
    姚敏，周恩超．从虚与毒论治慢性肾衰竭[J]．四川中医，2016，34(11)：34-36．
    [5]
    尹浩，周恩超.周恩超教授从毒论治慢性肾衰竭常用药对介绍[J].浙江中医药大学学报，2016，12(40):932-935.
    [6]
    SAYHAN MB，KANTER M，OGUZ S，et al．Protective effect of Urtica dioica L． on renal ischemia/reperfusion injury in rat[J]．J Mol Histol，2012，43(6)：691-698．
    [7]
    CHEN G，FUYR，WU XH．Protective effect of Salvia miltiorrhiza extract against renal ischemia-reperfusion-induced injury in rats[J]．Molecules，2012，17(2)：1191-1202．
    [8]
    刘世杰，周世文．顺铂对原代培养兔近端肾小管上皮细胞酶活力的影响以及牛磺酸、三七皂苷和茵陈素的保护作用[J]．中国药理学通报，1999，15(5)：452-455．
    [9]
    孙响波，于妮娜．六月雪治疗肾脏疾病探源[J]．中医药导报，2013，19(10)：127-128．
    [10]
    王建平，张海燕，傅旭春．土茯苓的化学成分和药理作用研究进展[J]．海峡药学，2013，25(1)：42-44．
    [11]
    赵春玲，李莉华，邬丽莎，等．黄芪注射液对兔缺血-再灌注肾损伤时IL-6和βFGF的影响[J]．中国中西医结合急救杂志，2001，8(4)：225-227．
    [12]
    楚晋，李林．山萸肉化学成分及其药理活性的研究[J]．中国自然医学杂志，1999(1)：46-48．
    [13]
    LU CY，HARTONO J，SENITKO M，et al．The inflammatory response to ischemic acute kidney injury：A result of the 'right stuff' in the 'wrong place'?[J]．Curr Opin Nephrol Hypertens，2007，16(2)：83-89．
    [14]
    CONG GT，CUI L，ZANG M，et al．Attenuation of renal ischemia/reperfusion injury by a polysaccharide from the roots of Dipsacus asperoides[J]．Int J Biol Macromol，2013，56：14-19．
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