Clinical Observation on the Effects of Qizhu Formula in Improving Postoperative Symptoms of Early Gastric Cancer and Preventing the Recurrence of Gastric Cancer

OBJECTIVE To observe the efficacy of Qizhu formula in improving qi and yin deficiency symptoms after gastric endoscopic submucosal dissection (ESD) for patients with early gastric cancer and preventing the recurrence of gastric cancer. METHODS 84 patients with early gastric cancer who had deficiency of qi and yin symptoms were randomly divided into 2 groups with 6 expulsion cases， 39 cases in the treatment group and 39 cases in the control group after ESD. The control group was treated with Weifuchun pills， while the treatment group was treated with Qizhu decoction for one year. Clinical recurrence rate， gastroscopy erosions， pathological scores， traditional Chinese medicine (TCM) syndrome scores and carcinoembryonic antigen (CEA) changes were observed in the 2 groups. RESULTS After the treatment， the recurrence rate was lower in the treatment group than that in the control group (5.13% vs 20.51%， P<0.05). Compared with the control group， the treatment group had less clinical symptoms (P<0.01)， erosions (P<0.05)， lower pathological scores (P<0.05) and CEA (P<0.05)， as well as significant relieves in stomachache， poor digestion and acid reflux symptoms (P<0.05). CONCLUSION Qizhu decoction can improve clinical symptoms， reduce gastric mucosal erosion， intestinal metaplasia and hyperplasia， and reduce the recurrence rate of gastric cancer with a remarkable therapeutic effect.