Volume 36 Issue 3
May  2020
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YUE Qin-fei, CHEN Ye-qing, FAN Xin-sheng. Mechanism of Jinshui Liujun Decoction in the Treatment of Chronic Obstructive Pulmonary Disease Based on Network Pharmacology[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(3): 358-364.
Citation: YUE Qin-fei, CHEN Ye-qing, FAN Xin-sheng. Mechanism of Jinshui Liujun Decoction in the Treatment of Chronic Obstructive Pulmonary Disease Based on Network Pharmacology[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(3): 358-364.

Mechanism of Jinshui Liujun Decoction in the Treatment of Chronic Obstructive Pulmonary Disease Based on Network Pharmacology

  • Publish Date: 2020-05-10
  • OBJECTIVE To explore the mechanism of Jinshui Liujun decoction in the treatment of chronic obstructive pulmonary disease (COPD) by network pharmacology. METHODS The chemical ingredients and corresponding targets of Jinshui Liujun decoction were retrieved from TCMSP platform. The relevant targets of COPD were obtained through the TTD, DisGeNET, GeneCardsand and CTD databases, the targets of drug chemical ingredients were mapped to the targets of COPD. The intersection targets and the efficacy components were obtained. Using STRING database and Cytoscape 3.7.2 software, component-target network model was constructed. The OmicShare open platform was used to perform gene function (GO) and the Kyoto Gene and Genome Encyclopedia (KEGG) enrichment analysis. RESULTS Jinshui Liujun decoction had 96 intersection targets for COPD, 435 efficacy components (The main components are quercetin, stigmasterol, kaempferol, β-sitosterol, naringin, ursolic acid, etc.), and 20 key targets which degree,betweenness and closeness are greater than average, including MAPK3, TNF, PPAR-γ, SIRTI, HMOX1, MAPK8, CAT, SIRT1, STAT3, etc. Enrichment analysis showed that the formula mainly involved the response to biological and chemical stimuli, various cell biological processes, cell proliferation, immunity, metabolism, etc. 17 signaling pathways including IL-17, Toll-like receptor, TNF, HIF-1, FoxO, TGF-β and ErbB, etc. play a role in the treatment of COPD. CONCLUSION Jinshui Liujun decoction can treat COPD through the synergy of multiple ingredients, multiple targets and multiple pathways, which provides basic data for in-depth exploration of the mechanism of Jinshui Liu jun decoction in the treatment of COPD.

     

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  • [1]
    王蕾,杨汀,王辰.2017年版慢性阻塞性肺疾病诊断、处理和预防全球策略解读[J].中国临床医生杂志,2017,45(1):104-108.
    [2]
    MIRZA S,CLAY RD,KOSLOW MA,et al.COPD guidelines:a review of the 2018 GOLD report[J].Mayo Clin Proc,2018,93(10):1488-1502.
    [3]
    戴蓓,蔡值,董莹,等.金水六君煎治疗慢性阻塞性肺疾病的疗效观察[J].中医药导报,2015,21(11):67-68.
    [4]
    〖JP2〗张文江,苗青,张琼,等.金水六君煎加味治疗慢性阻塞性肺疾病急性加重期的临床观察[J].中国中医急症,2014,23(10):1836-1838.〖JP〗
    [5]
    张介宾.景岳全书[M].李继明,等,整理.北京:人民卫生出版社,2007:1291.
    [6]
    ZHENG XR,ZHANG LY,CHEN J,et al.Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease[J].Biomedecine Pharmacother,2018,108:1141-1151.
    [7]
    黄明儒,许忠波,何帆,等.补中益气汤加味联合缩唇呼吸疗法对慢性阻塞性肺疾病稳定期患者血清TNF-α,IL-8,IL-6,IL-1β,Cys-C的影响[J].中国实验方剂学杂志,2019,25(22):60-65.
    [8]
    关英,阿选德.慢性阻塞性肺疾病患者FeNO与外周血IL-8、TNF-α和VEGF水平的相关性研究[J].中国现代医学杂志,2019,29(21):60-64.
    [9]
    吕明圣,张沂,张迪,等.中医药多靶点干预慢性阻塞性肺疾病机制研究概述[J].中医杂志,2019,60(19):1697-1700.
    [10]
    吴洁,姚兆敏,方伟,等.烟雾所致轻度稳定期COPD小鼠肺组织中MRP1表达增加与Nrf2信号通路有关[J].中国药理学通报,2019,35(2):272-277.
    [11]
    吴凡,李泽庚,董昌武,等.芪白平肺胶囊通过调节SIRT1/FoxO3a通路改善COPD气虚痰瘀证大鼠炎症及氧化应激状态[J].细胞与分子免疫学杂志,2019,35(2):115-120.
    [12]
    谢文英,季书,尚立芝,等.二陈汤加味对COPD患者缺氧诱导因子-1α及沉默信息调节因子1的影响[J].中国实验方剂学杂志,2017,23(10):155-162.
    [13]
    〖JP2〗CHEN TL,ZHU GL,WANG JN,et al.Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury[J].Int J Clin Exp Pathol,2015,8(3):2311-2320.〖JP〗
    [14]
    YU D,LIU X,ZHANG GX,et al.Isoliquiritigenin inhibits cigarette smoke-induced COPD by attenuating inflammation and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways[J].Front Pharmacol,2018,9:1001.
    [15]
    DU WW,AN YL,HE XD,et al.Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage[J].Oxid Med Cell Longev,2018,2018:1610751.
    [16]
    TSOU YA,HUANG HJ,LIN WW,et al.Lead screening for chronic obstructive pulmonary disease of IKK2 inhibited by traditional Chinese medicine[J].Evid Based Complement Alternat Med,2014,2014:465025.
    [17]
    SINGH D,AGUSTI A,ANZUETO A,et al.Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Lung Disease:the GOLD science committee report 2019[J].Eur Respir J,2019,53(5):1900164.
    [18]
    童卫泉,杨宏宽,夏婷婷,等.雷帕霉素对慢性阻塞性肺疾病大鼠气道重塑中血管内皮生长因子表达作用的研究[J].中国全科医学,2016,19(36):4484-4488,4494.
    [19]
    李丹丹,任卫英,朱蕾.p38丝裂原活化蛋白激酶在肺部疾病中的研究进展[J].复旦学报(医学版),2018,45(3):413-417.
    [20]
    ZHANG WB,WANG G,ZHOU SJ.Protective effects of isoliquiritigenin on LPS-induced acute lung injury by activating PPAR-γ[J].Inflammation,2018,41(4):1290-1296.
    [21]
    田刚,陈恩竹,于文成.PPAR-γ和MMP-9对COPD病人气道杯状细胞增生和MUC5AC表达的影响[J].青岛大学医学院学报,2012,48(3):244-246.
    [22]
    LIU J, YAO J, ZHANG J. Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB[J]. J Microbiol Biotechnol,2018,2018:10061.
    [23]
    LIN Y,TAN D,KAN QN,et al.The protective effect of naringenin on airway remodeling after Mycoplasma pneumoniae<\i> infection by inhibiting autophagy-mediated lung inflammation and fibrosis[J].Mediators Inflamm,2018,2018:8753894.
    [24]
    YANG T,WANG H,LI YH,et al.Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation,mucus hypersecretion and airway remodeling in mice[J].Int Immunopharmacol,2020,81:106036.
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