Discussion on Curative Effect and Mechanism of Treating Diarrhea Predominant Irritable Bowel Syndrome with Liver-Stagnation and Spleen-Deficiency Based on "Purging Wood from Earth"

OBJECTIVE To observe the clinical effect of treating diarrhea predominant irritable bowel syndrome (IBS) with liver-stagnation and spleen-deficiency based on "purging wood from earth" and to discuss its mechanism. METHODS 60 patients from January， 2017 to December， 2018 in the Spleen-Stomach Department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine were enrolled in the case group. They were divided into the observation group and the control group with 30 cases each. The observation group was given modified Lichang Drink while the control group was given pinaverium bromide (Dicetel). The course lasted four weeks. Patients' indexes in these aspects were observed before and after the treatment: Scores of anxiety-depression scale [Zung self-rating anxiety scale (SAS) and self-rating depression scale (SDS) ]， indexes of anorectal manometry dynamics [anal sphincter resting pressure (ARP)， rectal resting pressure (RRP)， initial rectal sensation and maximum tolerance threshold]， clinical effects and recurrence rate after follow-up. RESULTS After treatment， scores of TCM syndrome in the two groups significantly decreased compared with those before treatment (P<0.05， P<0.01) and the observation group was better than those in the control group (P<0.05， P<0.01). The total recovery rate in the observation group was higher than that in the control group (P<0.05). Patients in the two groups had significant lower scores of anxiety-depression scale than before (P<0.05， P<0.01) and the observation group was better (P<0.05). There was significant difference in ARP， RRP， initial rectal sensation and maximum tolerance threshold in both groups before and after treatment (P<0.05) but no significant difference between two groups (P>0.05). CONCLUSION Modified Lichang Drink shows obvious curative effect in treating diarrhea predominant with liver-stagnation and spleen-deficiency and the recurrence is low， which might function through regulating gastrointestinal motility and decreasing rectal sensitivity.