Effects of Jiahua Tablet on Renal Injury Index of Patients with Nephropathy after Coronary Angiography or PCI

OBJECTIVE To observe the effect of Jiahua tablet on glomerular filtration function and renal tubular injury indexes in patients with contrast-induced nephropathy after coronary angiography or interventional therapy， and to evaluate its efficacy in the prevention and treatment of contrast-induced nephropathy， in order to provide a new clinical evidence for the diagnosis and treatment of contrast-induced nephropathy in traditional Chinese medicine (TCM). METHODS 80 patients with coronary angiography or interventional treatment were selected and randomly divided into treatment group and control group with 40 cases each. Based on such routine treatments of control group as antihypertensive methods (calcium antagonist， β receptor blocker， α receptor blocker， diuretics)， statins and aspirin， the treatment group was treated with 4 Jiahua tablets at a time， 3 times per day from preoperative 72 h till postoperative 72 h in a week. Such changes of index were observed as serum creatinine (Scr)， serum urea nitrogen (BUN)， glomerular filtration rate (eGFR)， urine N-acetyl-β-D-glycosaminidase (NAG) and urine β-galactosidase (GAL). RESULTS After postoperative 24 h， the levels of Scr， BUN， NAG and GAL in the two groups were significantly higher than those of preoperation， and the level of eGFR was markedly lower than that before operation(P<0.05， P<0.01). The activities of NAG and GAL in the treatment group was significantly lower than that of the control group (P<0.05， P<0.01). The postoperative 72 h levels of Scr， BUN， NAG， GAL and eGFR in the treatment group were basically the same as those before the operation (P>0.05).The postoperative 72 h levels of Scr， BUN and NAG in the control group were significantly higher than those of the preoperation， and the level of eGFR was significantly lower than that before the operation (P<0.01). The levels of Scr， BUN， and the activity of NAG and GAL in the treatment group were significantly lower than those of the control group， while the level of eGFR was significantly higher than that of the control group (P<0.05， P<0.01). CONCLUSION Jiahua tablets can improve the expression of renal injury indexes such as Scr， BUN， NAG and GAL， and exert a better renal protective effect， thereby achieving the purpose of preventing and treating contrast-induced nephropathy.